Human development requires intricate cell specification and communication pathways that
allow an embryo to generate and appropriately connect more than 200 different cell types …

A determinant of axon regeneration is the intrinsic growth ability of injured neurons, which
dictates a battery of injury responses in axons and cell bodies. While some of these …

Type-specific dendrite morphology is a hallmark of the neuron and has important functional
implications in determining what signals a neuron receives and how these signals are …

Neurons in the central nervous system (CNS) lose their ability to regenerate early in
development, but the underlying mechanisms are unknown. By screening genes …

Neurodegenerative diseases are disabling and fatal neurological disorders that currently
lack effective treatment. Neural stem cell (NSC) transplantation has been studied as a …

Histone methylation regulates chromatin structure and transcription. The recently identified
histone demethylase lysine-specific demethylase 1 (LSD1) is chemically restricted to …

Granule cells (GCs) are the most numerous cell type in the cerebellum and indeed, in the
brain: at least 99% of all cerebellar neurons are granule cells. In this review article, we first …

Failure of axon regeneration after central nervous system (CNS) injuries results in
permanent functional deficits. Numerous studies in the past suggested that blocking …

Astrocytes show unique anatomical, morphological, and metabolic features to take up
substrates from the blood and metabolize them for local delivery to active synapses to …

One does not often look to analytic cubism for insights into the control of the cell cycle, but
Pablo Picasso beautifully encapsulated the fundamentals when he said that “every act of …