The heat shock response (HSR) is a gene regulatory program controlling expression of
molecular chaperones implicated in aging, cancer, and neurodegenerative disease. Long …

An extensive network of chaperones and folding factors is responsible for maintaining a
functional proteome, which is the basis for cellular life. The underlying proteostatic …

Spatial compartmentalization is a key facet of protein quality control that serves to store
disassembled or non-native proteins until triage to the refolding or degradation machinery …

A major consequence of aging and stress, in yeast to humans, is an increased accumulation
of protein aggregates at distinct sites within the cells. Using genetic screens …

The ESCRT machinery plays a pivotal role in membrane-remodeling events across multiple
cellular processes including nuclear envelope repair and reformation, nuclear pore complex …

The resilience of cellular proteostasis declines with age, which drives protein aggregation
and compromises viability. The nucleus has emerged as a key quality control compartment …

Mitochondria consist of hundreds of proteins, most of which are inaccessible to the
proteasomal quality control system of the cytosol. How cells stabilize the mitochondrial …

Background Paraptosis is a programmed cell death characterized by cytoplasmic
vacuolation, which has been explored as an alternative method for cancer treatment and is …

Protein quality control mechanisms oversee numerous aspects of protein lifetime. From the
point of protein synthesis, protein homeostasis machineries take part in folding …

Endosomal sorting complex required for transport (ESCRT) is required for maintenance of
nuclear functions and prevention of neurodegenerative diseases. The budding yeast …