Covering: up to June 2020 Ribosomally-synthesized and post-translationally modified
peptides (RiPPs) are a large group of natural products. A community-driven review in 2013 …

Environmental DNA sequencing has revealed the expansive biodiversity of microorganisms
and clarified the relationship between host-associated microbial communities and host …

CRISPR-Cas systems provide microbes with adaptive immunity to infectious nucleic acids
and are widely employed as genome editing tools. These tools use RNA-guided Cas …

Challenges in cultivating microorganisms have limited the phylogenetic diversity of currently
available microbial genomes. This is being addressed by advances in sequencing …

Metagenomic datasets contain billions of protein sequences that could greatly enhance
large-scale functional annotation and structure prediction. Utilizing this enormous resource …

Despite decades of work by structural biologists, there are still~ 5200 protein families with
unknown structure outside the range of comparative modeling. We show that Rosetta …

Viruses are the most abundant biological entities on Earth, but challenges in detecting,
isolating, and classifying unknown viruses have prevented exhaustive surveys of the global …

Abstract The Integrated Microbial Genomes with Microbiome Samples (IMG/M: https://img.
jgi. doe. gov/m/) system contains annotated DNA and RNA sequence data of (i) archaeal …

A process of global importance in carbon cycling is the remineralization of algae biomass by
heterotrophic bacteria, most notably during massive marine algae blooms. Such blooms can …

Bacterial metabolism plays a fundamental role in gut microbiota ecology and host–
microbiome interactions. Yet the metabolic capabilities of most gut bacteria have remained …