Polycyclic polyprenylated acylphloroglucinols (PPAPs) are a class of hybrid natural products
sharing the mevalonate/methylerythritol phosphate and polyketide biosynthetic pathways …

Since their discovery in the 1980s and 1990s, the human protein lysine acetyltransferase
encoded by the paralogous p300 and CBP genes has received much interest. p300/CBP …

The histone acetyltransferase (HAT) p300/CBP is a transcriptional coactivator implicated in
many gene regulatory pathways and protein acetylation events. Although p300 inhibitors …

Epigenetics refers to heritable changes that are not encoded in the DNA sequence itself, but
play an important role in the control of gene expression. In mammals, epigenetic …

Post-translational modifications of DNA and histones are epigenetic mechanisms, which
affect the chromatin structure, ultimately leading to gene expression changes. A number of …

Protein acetylation has emerged as a major mechanism in regulating cellular metabolism.
Whereas most glycolytic steps are reversible, the reaction catalyzed by pyruvate kinase is …

In eukaryotic cells, gene transcription is regulated by sequence-specific DNA-binding
transcription factors that recognize promoter and enhancer elements near the transcriptional …

Caloric restriction, be it constant or intermittent, is reputed to have health-promoting and
lifespan-extending effects. Caloric restriction mimetics (CRMs) are compounds that mimic …

p300 acts as a transcription coactivator and an acetyltransferase that plays an important role
in tumourigenesis and progression. In previous studies, it has been confirmed that p300 is …

Abstract Garcinia kola Heckel (Clusiaceae) is a tree indigenous to West and Central Africa.
All plant parts, but especially the seeds, are of value in local folklore medicine. Garcinia kola …