Towards controlled drug delivery in brain tumors with microbubble-enhanced focused ultrasound
Brain tumors are particularly challenging malignancies, due to their location in a structurally
and functionally distinct part of the human body–the central nervous system (CNS). The CNS …
and functionally distinct part of the human body–the central nervous system (CNS). The CNS …
Nanotherapeutic treatment of the invasive glioblastoma tumor microenvironment
Glioblastoma (GBM) is the most common malignant adult brain cancer with no curative
treatment strategy. A significant hurdle in GBM treatment is effective therapeutic delivery to …
treatment strategy. A significant hurdle in GBM treatment is effective therapeutic delivery to …
[HTML][HTML] Meningioma: current updates on genetics, classification, and mouse modeling
F Szulzewsky, HN Thirimanne… - Upsala Journal of …, 2024 - ncbi.nlm.nih.gov
Meningiomas, the most common primary brain tumors in adults, are often benign and
curable by surgical resection. However, a subset is of higher grade, shows aggressive …
curable by surgical resection. However, a subset is of higher grade, shows aggressive …
[HTML][HTML] Recent advances in development and delivery of non-viral nucleic acid therapeutics for brain tumor therapy
D Kögel, A Temme, A Aigner - Pharmacology & therapeutics, 2024 - Elsevier
High grade gliomas (HGG) are a group of CNS tumors refractory to currently existing
therapies, which routinely leads to early recurrence and a dismal prognosis. Recent …
therapies, which routinely leads to early recurrence and a dismal prognosis. Recent …
Elevated fibroblast growth factor‐inducible 14 expression transforms proneural‐like gliomas into more aggressive and lethal brain cancer
High‐grade gliomas (HGGs) are aggressive, treatment‐resistant, and often fatal human
brain cancers. The TNF‐like weak inducer of apoptosis (TWEAK)/fibroblast growth factor …
brain cancers. The TNF‐like weak inducer of apoptosis (TWEAK)/fibroblast growth factor …
Multiparametric longitudinal profiling of RCAS-tva-Induced PDGFB-driven experimental glioma
Glioblastomas are incurable primary brain tumors harboring a heterogeneous landscape of
genetic and metabolic alterations. Longitudinal imaging by MRI and [18F] FET-PET …
genetic and metabolic alterations. Longitudinal imaging by MRI and [18F] FET-PET …
[HTML][HTML] ERK signaling promotes resistance to TRK kinase inhibition in NTRK fusion-driven glioma mouse models
S Schmid, ZR Russell, AS Yamashita, ME West… - Cell reports, 2024 - cell.com
Pediatric-type high-grade gliomas frequently harbor gene fusions involving receptor tyrosine
kinase genes, including neurotrophic tyrosine kinase receptor (NTRK) fusions. Clinically …
kinase genes, including neurotrophic tyrosine kinase receptor (NTRK) fusions. Clinically …
Glioblastoma
EA Maher, RM Bachoo - Rosenberg's Molecular and Genetic Basis of …, 2025 - Elsevier
Glioblastoma (GBM) is a disease that strikes without warning, often manifested by new onset
seizure or a few days of progressive focal weakness, numbness, or headache, yet …
seizure or a few days of progressive focal weakness, numbness, or headache, yet …
Myeloid cell heterogeneity in the tumor microenvironment and therapeutic implications for childhood central nervous system (CNS) tumors
S Kalathoor, S Rajendran, A Canella, R Raval… - Journal of …, 2023 - Elsevier
Central nervous system (CNS) tumors are the most common type of solid tumors in children
and the leading cause of cancer deaths in ages 0–14. Recent advances in the field of tumor …
and the leading cause of cancer deaths in ages 0–14. Recent advances in the field of tumor …
Pediatric Glioma Models Provide Insights into Tumor Development and Future Therapeutic Strategies
In depth study of pediatric gliomas has been hampered due to difficulties in accessing
patient tissue and a lack of clinically representative tumor models. Over the last decade …
patient tissue and a lack of clinically representative tumor models. Over the last decade …