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Biogenesis and regulatory roles of circular RNAs
Covalently closed, single-stranded circular RNAs can be produced from viral RNA genomes
as well as from the processing of cellular housekee** noncoding RNAs and precursor …
as well as from the processing of cellular housekee** noncoding RNAs and precursor …
Best practice standards for circular RNA research
AF Nielsen, A Bindereif, I Bozzoni, M Hanan… - Nature …, 2022 - nature.com
Circular RNAs (circRNAs) are formed in all domains of life and via different mechanisms.
There has been an explosion in the number of circRNA papers in recent years; however, as …
There has been an explosion in the number of circRNA papers in recent years; however, as …
Detecting circular RNAs: bioinformatic and experimental challenges
L Szabo, J Salzman - Nature Reviews Genetics, 2016 - nature.com
The pervasive expression of circular RNAs (circRNAs) is a recently discovered feature of
gene expression in highly diverged eukaryotes. Numerous algorithms that are used to detect …
gene expression in highly diverged eukaryotes. Numerous algorithms that are used to detect …
Statistically based splicing detection reveals neural enrichment and tissue-specific induction of circular RNA during human fetal development
Background The pervasive expression of circular RNA is a recently discovered feature of
gene expression in highly diverged eukaryotes, but the functions of most circular RNAs are …
gene expression in highly diverged eukaryotes, but the functions of most circular RNAs are …
The circular RNA circBIRC6 participates in the molecular circuitry controlling human pluripotency
CY Yu, TC Li, YY Wu, CH Yeh, W Chiang… - Nature …, 2017 - nature.com
Accumulating evidence indicates that circular RNAs (circRNAs) are abundant in the human
transcriptome. However, their involvement in biological processes, including pluripotency …
transcriptome. However, their involvement in biological processes, including pluripotency …
Biogenesis, identification, and function of exonic circular RNAs
Circular RNAs (circRNAs) arise during post‐transcriptional processes, in which a single‐
stranded RNA molecule forms a circle through covalent binding. Previously, circRNA …
stranded RNA molecule forms a circle through covalent binding. Previously, circRNA …
An improved method for circular RNA purification using RNase R that efficiently removes linear RNAs containing G-quadruplexes or structured 3′ ends
Thousands of eukaryotic protein-coding genes generate circular RNAs that have covalently
linked ends and are resistant to degradation by exonucleases. To prove their circularity as …
linked ends and are resistant to degradation by exonucleases. To prove their circularity as …
Artifacts and biases of the reverse transcription reaction in RNA sequencing
RNA sequencing has spurred a significant number of research areas in recent years. Most
protocols rely on synthesizing a more stable complementary DNA (cDNA) copy of the RNA …
protocols rely on synthesizing a more stable complementary DNA (cDNA) copy of the RNA …
Recent advances in cancer fusion transcript detection
Extensive investigation of gene fusions in cancer has led to the discovery of novel
biomarkers and therapeutic targets. To date, most studies have neglected chromosomal …
biomarkers and therapeutic targets. To date, most studies have neglected chromosomal …
Circular RNA enrichment in platelets is a signature of transcriptome degradation
AA Alhasan, OG Izuogu, HH Al-Balool… - Blood, The Journal …, 2016 - ashpublications.org
In platelets, splicing and translation occur in the absence of a nucleus. However, the integrity
and stability of mRNAs derived from megakaryocyte progenitor cells remain poorly …
and stability of mRNAs derived from megakaryocyte progenitor cells remain poorly …