Biogenesis and regulatory roles of circular RNAs

L Yang, JE Wilusz, LL Chen - Annual review of cell and …, 2022 - annualreviews.org
Covalently closed, single-stranded circular RNAs can be produced from viral RNA genomes
as well as from the processing of cellular housekee** noncoding RNAs and precursor …

Best practice standards for circular RNA research

AF Nielsen, A Bindereif, I Bozzoni, M Hanan… - Nature …, 2022 - nature.com
Circular RNAs (circRNAs) are formed in all domains of life and via different mechanisms.
There has been an explosion in the number of circRNA papers in recent years; however, as …

Detecting circular RNAs: bioinformatic and experimental challenges

L Szabo, J Salzman - Nature Reviews Genetics, 2016 - nature.com
The pervasive expression of circular RNAs (circRNAs) is a recently discovered feature of
gene expression in highly diverged eukaryotes. Numerous algorithms that are used to detect …

Statistically based splicing detection reveals neural enrichment and tissue-specific induction of circular RNA during human fetal development

L Szabo, R Morey, NJ Palpant, PL Wang, N Afari… - Genome biology, 2015 - Springer
Background The pervasive expression of circular RNA is a recently discovered feature of
gene expression in highly diverged eukaryotes, but the functions of most circular RNAs are …

The circular RNA circBIRC6 participates in the molecular circuitry controlling human pluripotency

CY Yu, TC Li, YY Wu, CH Yeh, W Chiang… - Nature …, 2017 - nature.com
Accumulating evidence indicates that circular RNAs (circRNAs) are abundant in the human
transcriptome. However, their involvement in biological processes, including pluripotency …

Biogenesis, identification, and function of exonic circular RNAs

I Chen, CY Chen, TJ Chuang - Wiley Interdisciplinary Reviews …, 2015 - Wiley Online Library
Circular RNAs (circRNAs) arise during post‐transcriptional processes, in which a single‐
stranded RNA molecule forms a circle through covalent binding. Previously, circRNA …

An improved method for circular RNA purification using RNase R that efficiently removes linear RNAs containing G-quadruplexes or structured 3′ ends

MS **ao, JE Wilusz - Nucleic acids research, 2019 - academic.oup.com
Thousands of eukaryotic protein-coding genes generate circular RNAs that have covalently
linked ends and are resistant to degradation by exonucleases. To prove their circularity as …

Artifacts and biases of the reverse transcription reaction in RNA sequencing

J Verwilt, P Mestdagh, J Vandesompele - Rna, 2023 - rnajournal.cshlp.org
RNA sequencing has spurred a significant number of research areas in recent years. Most
protocols rely on synthesizing a more stable complementary DNA (cDNA) copy of the RNA …

Recent advances in cancer fusion transcript detection

R Dorney, BP Dhungel, JEJ Rasko… - Briefings in …, 2023 - academic.oup.com
Extensive investigation of gene fusions in cancer has led to the discovery of novel
biomarkers and therapeutic targets. To date, most studies have neglected chromosomal …

Circular RNA enrichment in platelets is a signature of transcriptome degradation

AA Alhasan, OG Izuogu, HH Al-Balool… - Blood, The Journal …, 2016 - ashpublications.org
In platelets, splicing and translation occur in the absence of a nucleus. However, the integrity
and stability of mRNAs derived from megakaryocyte progenitor cells remain poorly …