Recent insights into the roles of circular RNAs in human brain development and neurologic diseases

S Najafi, SMA Zarch, J Majidpoor, S Pordel… - International Journal of …, 2023 - Elsevier
Circular RNAs (circRNAs) are a novel class of non-coding RNAs. They are single-stranded
RNA transcripts characterized with a closed loop structure making them resistant to …

Circular RNAs: expression, localization, and therapeutic potentials

Q Yang, F Li, AT He, BB Yang - Molecular therapy, 2021 - cell.com
Circular RNAs (circRNAs) are RNAs with a unique circular structure that is generated from
back-splicing processes. These circular molecules were discovered more than 40 years ago …

The role of noncoding RNAs in Parkinson's disease: biomarkers and associations with pathogenic pathways

MC Kuo, SCH Liu, YF Hsu, RM Wu - Journal of biomedical science, 2021 - Springer
The discovery of various noncoding RNAs (ncRNAs) and their biological implications is a
growing area in cell biology. Increasing evidence has revealed canonical and noncanonical …

Differentially expressed circular RNAs in peripheral blood mononuclear cells of patients with Parkinson's disease

S Ravanidis, A Bougea, D Karampatsi… - Movement …, 2021 - Wiley Online Library
Background New noninvasive and affordable molecular approaches that will complement
current practices and increase the accuracy of Parkinson's disease (PD) diagnosis are …

Circular RNAs: the brain transcriptome comes full circle

A Gokool, CT Loy, GM Halliday, I Voineagu - Trends in Neurosciences, 2020 - cell.com
Circular RNAs (circRNAs) are a class of RNA molecules with a covalently closed loop
structure formed by back-splicing of exon–exon junctions. The detection of circRNAs across …

A new perspective on Alzheimer's disease: microRNAs and circular RNAs

SZ Abidin, NA Mat Pauzi, NI Mansor, NI Mohd Isa… - Frontiers in …, 2023 - frontiersin.org
microRNAs (miRNAs) play a multifaceted role in the pathogenesis of Alzheimer's disease
(AD). miRNAs regulate several aspects of the disease, such as Aβ metabolism, tau …

Insights into the multifaceted role of circular RNAs: implications for Parkinson's disease pathogenesis and diagnosis

E Doxakis - npj Parkinson's Disease, 2022 - nature.com
Parkinson's disease (PD) is a complex, age-related, neurodegenerative disease whose
etiology, pathology, and clinical manifestations remain incompletely understood. As a result …

Genome-wide, integrative analysis of circular RNA dysregulation and the corresponding circular RNA-microRNA-mRNA regulatory axes in autism

YJ Chen, CY Chen, TL Mai, CF Chuang… - Genome …, 2020 - genome.cshlp.org
Circular RNAs (circRNAs), a class of long noncoding RNAs, are known to be enriched in
mammalian neural tissues. Although a wide range of dysregulation of gene expression in …

Circular RNAs in cardiovascular diseases

X Mei, SY Chen - Pharmacology & therapeutics, 2022 - Elsevier
In eukaryotes, precursor mRNAs (pre-mRNAs) produce a unique class of biologically active
molecules namely circular RNAs (circRNAs) with a covalently closed-loop structure via back …

MAGCDA: a multi-hop attention graph neural networks method for CircRNA-disease association prediction

L Wang, ZW Li, ZH You, DS Huang… - IEEE Journal of …, 2023 - ieeexplore.ieee.org
With a growing body of evidence establishing circular RNAs (circRNAs) are widely exploited
in eukaryotic cells and have a significant contribution in the occurrence and development of …