TRP (transient receptor potential) ion channel family: structures, biological functions and therapeutic interventions for diseases

M Zhang, Y Ma, X Ye, N Zhang, L Pan… - Signal Transduction and …, 2023 - nature.com
Transient receptor potential (TRP) channels are sensors for a variety of cellular and
environmental signals. Mammals express a total of 28 different TRP channel proteins, which …

Omics-based biomarkers discovery for Alzheimer's disease

Q Aerqin, ZT Wang, KM Wu, XY He, Q Dong… - Cellular and Molecular …, 2022 - Springer
Alzheimer's disease (AD) is the most common neurodegenerative disorders presenting with
the pathological hallmarks of amyloid plaques and tau tangles. Over the past few years …

Microbial infection promotes amyloid pathology in a mouse model of Alzheimer's disease via modulating γ-secretase

M Zhao, G Ma, X Yan, X Li, E Wang, XX Xu… - Molecular …, 2024 - nature.com
Microbial infection as a type of environmental risk factors is considered to be associated with
long-term increased risk of dementia, including Alzheimer's disease (AD). AD is …

[HTML][HTML] Autophagy, a double-edged sword for oral tissue regeneration

X Xu, J Wang, Y ** young brain and risk for neuropsychiatric disorders
AM Alex, C Buss, EP Davis, G de Los Campos… - Biological …, 2023 - Elsevier
Imaging genetics provides an opportunity to discern associations between genetic variants
and brain imaging phenotypes. Historically, the field has focused on adults and adolescents; …

Functional genomics identify causal variant underlying the protective CTSH locus for Alzheimer's disease

Y Li, M Xu, BL **ang, X Li, DF Zhang, H Zhao… - …, 2023 - nature.com
Alzheimer's disease (AD) is the most prevalent age-related neurodegenerative disease,
which has a high heritability of up to 79%. Exploring the genetic basis is essential for …

Molecular docking and dynamics simulation approach of Camellia sinensis leaf extract derived compounds as potential cholinesterase inhibitors

ME Hosen, MS Rahman, MO Faruqe… - In Silico …, 2023 - Springer
The tea plant (Camellia sinensis) belongs to the family Theaceae and contains many
phytochemicals that are effective against various diseases, including neurodegenerative …

Mitochondrial-targeted antioxidant MitoQ-mediated autophagy: a novel strategy for precise radiation protection

X Bao, X Liu, Q Wu, F Ye, Z Shi, D Xu, J Zhang, Z Dou… - Antioxidants, 2023 - mdpi.com
Radiotherapy (RT) is one of the most effective cancer treatments. However, successful
radiation protection for normal tissue is a clinical challenge. Our previous study observed …

[HTML][HTML] Evaluation of dimercaptosuccinic acid-coated iron nanoparticles immunotargeted to amyloid beta as MRI contrast agents for the diagnosis of Alzheimer's …

M Ulanova, L Gloag, A Bongers, CK Kim, HTK Duong… - Cells, 2023 - mdpi.com
Nanoparticle-based magnetic contrast agents have opened the potential for magnetic
resonance imaging (MRI) to be used for early non-invasive diagnosis of Alzheimer's disease …

Corydecusines AH, new phthalideisoquinoline hemicetal alkaloids from the bulbs of Corydalis decumbens inhibit Tau pathology by activating autophagy mediated by …

S Li, RC Luo, ZZ Liang, BD Zhang, YL Wei, HY Wen… - Bioorganic …, 2024 - Elsevier
Twelve phthalideisoquinoline hemiacetal alkaloids including eight new ones (1–8) and one
natural alkaloid characterized by an aziridine moiety with unassigned NMR data (9), were …