The extracellular matrix is a fundamental, core component of all tissues and organs, and is
essential for the existence of multicellular organisms. From the earliest stages of organism …

Rho GTPases are a family of small G proteins that regulate a wide array of cellular
processes related to their key roles controlling the cytoskeleton. Cancer is a multistep …

Directional cell migration normally relies on a variety of external signals, such as chemical,
mechanical, or electrical, which instruct cells in which direction to move. Many of the major …

Cell polarization exists in a variety of tissues to regulate cell behaviors and functions. Space
constraint (spatially limiting cell extension) and adhesion induction (guiding adhesome …

Tissue engineering is a promising strategy for the repair and regeneration of damaged
tissues or organs. Biomaterials are one of the most important components in tissue …

Lung cancer is one of the common malignant tumors that threaten human life with serious
incidence and high mortality. According to the histopathological characteristics, lung cancer …

While nanoscale modification of a biomaterial surface is known to influence various cell
behaviors, it is unclear whether there is an optimal nanospacing of a bioactive ligand with …

The 3D architecture of tissues bearing tumors impacts on the mechanical microenvironment
of cancer, the accessibility of stromal cells, and the routes of invasion. A myriad of intrinsic …

Biological cells and tissues are continuously subjected to mechanical stress and strain cues
from their surrounding substrate. How these forces modulate cell and tissue behavior is a …

Extracellular matrix (ECM) proteins containing cell‐attachable Arg‐Gly‐Asp (RGD)
sequences exhibit variable bridging and non‐bridging in fibronectin‐collagen and laminin …