[HTML][HTML] Comparison of silver and molybdenum microfocus X-ray sources for single-crystal structure determination
The quality of diffraction data obtained using silver and molybdenum microsources has been
compared for six model compounds with a wide range of absorption factors. The …
compared for six model compounds with a wide range of absorption factors. The …
Ribosome-targeting antibiotics: modes of action, mechanisms of resistance, and implications for drug design
J Lin, D Zhou, TA Steitz, YS Polikanov… - Annual review of …, 2018 - annualreviews.org
Genetic information is translated into proteins by the ribosome. Structural studies of the
ribosome and of its complexes with factors and inhibitors have provided invaluable …
ribosome and of its complexes with factors and inhibitors have provided invaluable …
Bacterial protein synthesis as a target for antibiotic inhibition
Protein synthesis occurs on macromolecular machines, called ribosomes. Bacterial
ribosomes and the translational machinery represent one of the major targets for antibiotics …
ribosomes and the translational machinery represent one of the major targets for antibiotics …
Pseudouridinylation of mRNA coding sequences alters translation
DE Eyler, MK Franco, Z Batool, MZ Wu… - Proceedings of the …, 2019 - National Acad Sciences
Chemical modifications of RNAs have long been established as key modulators of
nonprotein-coding RNA structure and function in cells. There is a growing appreciation that …
nonprotein-coding RNA structure and function in cells. There is a growing appreciation that …
[HTML][HTML] mRNA decoding in human is kinetically and structurally distinct from bacteria
In all species, ribosomes synthesize proteins by faithfully decoding messenger RNA (mRNA)
nucleotide sequences using aminoacyl-tRNA substrates. Current knowledge of the …
nucleotide sequences using aminoacyl-tRNA substrates. Current knowledge of the …
Structural and mechanistic basis for translation inhibition by macrolide and ketolide antibiotics
Macrolides and ketolides comprise a family of clinically important antibiotics that inhibit
protein synthesis by binding within the exit tunnel of the bacterial ribosome. While these …
protein synthesis by binding within the exit tunnel of the bacterial ribosome. While these …
Retapamulin-assisted ribosome profiling reveals the alternative bacterial proteome
The use of alternative translation initiation sites enables production of more than one protein
from a single gene, thereby expanding the cellular proteome. Although several such …
from a single gene, thereby expanding the cellular proteome. Although several such …
Structural insights into the mechanism of overcoming Erm-mediated resistance by macrolides acting together with hygromycin-A
The ever-growing rise of antibiotic resistance among bacterial pathogens is one of the top
healthcare threats today. Although combination antibiotic therapies represent a potential …
healthcare threats today. Although combination antibiotic therapies represent a potential …
A selective antibiotic for Lyme disease
Lyme disease is on the rise. Caused by a spirochete Borreliella burgdorferi, it affects an
estimated 500,000 people in the United States alone. The antibiotics currently used to treat …
estimated 500,000 people in the United States alone. The antibiotics currently used to treat …
Structures of proline-rich peptides bound to the ribosome reveal a common mechanism of protein synthesis inhibition
With bacterial resistance becoming a serious threat to global public health, antimicrobial
peptides (AMPs) have become a promising area of focus in antibiotic research. AMPs are …
peptides (AMPs) have become a promising area of focus in antibiotic research. AMPs are …