Genetic information is translated into proteins by the ribosome. Structural studies of the
ribosome and of its complexes with factors and inhibitors have provided invaluable …

Protein synthesis occurs on macromolecular machines, called ribosomes. Bacterial
ribosomes and the translational machinery represent one of the major targets for antibiotics …

In all species, ribosomes synthesize proteins by faithfully decoding messenger RNA (mRNA)
nucleotide sequences using aminoacyl-tRNA substrates. Current knowledge of the …

The quality of diffraction data obtained using silver and molybdenum microsources has been
compared for six model compounds with a wide range of absorption factors. The …

Chemical modifications of RNAs have long been established as key modulators of
nonprotein-coding RNA structure and function in cells. There is a growing appreciation that …

The use of alternative translation initiation sites enables production of more than one protein
from a single gene, thereby expanding the cellular proteome. Although several such …

Macrolides and ketolides comprise a family of clinically important antibiotics that inhibit
protein synthesis by binding within the exit tunnel of the bacterial ribosome. While these …

With bacterial resistance becoming a serious threat to global public health, antimicrobial
peptides (AMPs) have become a promising area of focus in antibiotic research. AMPs are …

Target protection proteins confer resistance to the host organism by directly binding to the
antibiotic target. One class of such proteins are the antibiotic resistance (ARE) ATP-binding …

Single-molecule fluorescence microscopy is uniquely suited for detecting transient
molecular recognition events, yet achieving the time resolution and statistics needed to …