1, 1, 1, 3, 3, 3-Hexafluoroisopropanol (HFIP) is a polar, strongly hydrogen bond-donating
solvent that has found numerous uses in organic synthesis due to its ability to stabilize ionic …

Transition-metal-catalyzed C–H activation has developed a contemporary approach to the
omnipresent area of retrosynthetic disconnection. Scientific researchers have been tempted …

The chemistry of nitrogen-centered radicals (NCRs) has plentiful applications in organic
synthesis, and they continue to expand as our understanding of these reactive species …

Over the past decade, the landscape of molecular synthesis has gained major impetus by
the introduction of late-stage functionalization (LSF) methodologies. C–H functionalization …

The term late-stage functionalization (LSF) is recent but is now frequently used in the field of
organic methodology development to describe transformations on complex molecules. Such …

Among numerous solvents available for chemical transformations, 1, 1, 1, 3, 3, 3-hexafluoro-
2-propanol (popularly known as HFIP) has attracted enough attention of the scientific …

The electrophilic halogenation of arenes is perhaps the simplest method to prepare aryl
halides, which are important structural motifs in agrochemicals, materials, and …

Aminium radical cations have been extensively studied as electrophilic aminating species
that readily participate in C–N bond forming processes with alkenes and arenes. However …

Aliphatic primary amines are prevalent in natural products, pharmaceuticals, and functional
materials. While a plethora of processes are reported for their synthesis, methods that …

Synthetic chemistry plays an indispensable role in drug discovery, contributing to hit
compounds identification, lead compounds optimization, candidate drugs preparation, and …