Many mechanisms underlying an effective immunotherapy-induced antitumour response are
transient and critically time dependent. This is equally true for several immunological events …

Improving surgical resection outcomes for locally aggressive tumors is key to inducing
durable locoregional disease control and preventing progression to metastatic disease …

Myocardial infarction (MI)-induced impaired cardiomyocyte (CM) mitochondrial function and
microenvironmental inflammatory cascades severely accelerate the progression of heart …

Local administration of drugs at tumor sites over an extended period of time shows potential
as a promising approach for cancer treatment. In the present study, the temperature-induced …

The recent use of PARP inhibitors (PARPi) in the maintenance treatment of ovarian tumor
has significantly improved the survival rates of cancer patients. However, the current oral …

The generation of non‐exhausted effector T‐cells depends on vaccine's spatiotemporal
profile, and untimely delivery and low targeting to lymph node (LN) paracortex by standard …

Cancer immunotherapy has revolutionized cancer treatment by leveraging the immune
system to target and eliminate tumor cells. Implantable biomaterials, such as hydrogels …

Toll-like receptor (TLR) agonists are being developed as anti-cancer therapeutics due to
their potent immunostimulatory properties. However, clinical trials testing TLR agonists as …

Hematopoietic progenitor cells (HPCs) in bone marrow with limited abilities for self-renewal
and differentiation continuously supply hematopoietic cells through life. When suffering …

The tumor microenvironment (TME) is well known for its immune suppressive role,
especially in solid tumors which are characterized by a thick, dense stroma. Apart from cell …