Recent advances in responsive hydrogels for diabetic wound healing

S Zhang, G Ge, Y Qin, W Li, J Dong, J Mei, R Ma… - Materials Today Bio, 2023 - Elsevier
Poor wound healing after diabetes mellitus remains a challenging problem, and its
pathophysiological mechanisms have not yet been fully elucidated. Persistent bleeding …

Current trends in polymer microneedle for transdermal drug delivery

KAS Al-Japairai, S Mahmood, SH Almurisi… - International journal of …, 2020 - Elsevier
Transdermal drug delivery using microneedles is increasingly gaining interest due to the
issues associated with oral drug delivery routes. Gastrointestinal route exposes the drug to …

Scarless wound healing programmed by core-shell microneedles

Y Zhang, S Wang, Y Yang, S Zhao, J You… - Nature …, 2023 - nature.com
Effective reprogramming of chronic wound healing remains challenging due to the limited
drug delivery efficacy hindered by physiological barriers, as well as the inappropriate dosing …

ROS-scavenging hydrogel to promote healing of bacteria infected diabetic wounds

H Zhao, J Huang, Y Li, X Lv, H Zhou, H Wang, Y Xu… - Biomaterials, 2020 - Elsevier
Bacterial infection has been a great threat to dermal wounds, especially to difficult-to-heal
diabetic wounds. It is known that reactive oxygen species (ROS) generated by wounds or …

[HTML][HTML] Stimuli-responsive transdermal microneedle patches

P Makvandi, R Jamaledin, G Chen… - Materials Today, 2021 - Elsevier
Microneedle (MN) patches consisting of miniature needles have emerged as a promising
tool to perforate the stratum corneum and translocate biomolecules into the dermis in a …

Responsive hydrogel dressings for intelligent wound management

S Wang, WY Wu, JCC Yeo, XYD Soo, W Thitsartarn… - …, 2023 - Wiley Online Library
Due to global aging problems, the rising number of patients suffering from chronic or hard‐to‐
heal acute wounds imposes a significant burden on healthcare systems. Wound healing is a …

Injectable reactive oxygen species‐responsive hydrogel dressing with sustained nitric oxide release for bacterial ablation and wound healing

J Yu, R Zhang, B Chen, X Liu, Q Jia… - Advanced Functional …, 2022 - Wiley Online Library
Skin wound healing strategies that promote sustainable healing, prevent bacterial infections,
and cause only mild irritation are urgently needed for open wound therapy. In this study, a …

Black phosphorus-loaded separable microneedles as responsive oxygen delivery carriers for wound healing

X Zhang, G Chen, Y Liu, L Sun, L Sun, Y Zhao - ACS nano, 2020 - ACS Publications
Oxygen carriers are attracting extensive interest in biomedical research and clinical
applications such as wound healing, alternative blood transfusion, and acute trauma …

A fully integrated closed‐loop system based on mesoporous microneedles‐iontophoresis for diabetes treatment

X Li, X Huang, J Mo, H Wang, Q Huang… - Advanced …, 2021 - Wiley Online Library
A closed‐loop system that can mini‐invasively track blood glucose and intelligently treat
diabetes is in great demand for modern medicine, yet it remains challenging to realize …

Hydrogel design strategies for drug delivery

CA Dreiss - Current opinion in colloid & interface science, 2020 - Elsevier
Hydrogels are water-swollen three-dimensional networks made of polymers, proteins, small
molecules or colloids. They constitute a versatile platform for drug delivery because of their …