Philadelphia chromosome–like acute lymphoblastic leukemia

SK Tasian, ML Loh, SP Hunger - Blood, The Journal of the …, 2017 - ashpublications.org
Philadelphia chromosome (Ph)-like acute lymphoblastic leukemia (ALL), also referred to as
BCR-ABL1–like ALL, is a high-risk subset with a gene expression profile that shares …

Biologic and therapeutic implications of genomic alterations in acute lymphoblastic leukemia

I Iacobucci, S Kimura, CG Mullighan - Journal of clinical medicine, 2021 - mdpi.com
Acute lymphoblastic leukemia (ALL) is the most successful paradigm of how risk-adapted
therapy and detailed understanding of the genetic alterations driving leukemogenesis and …

Molecular classification improves risk assessment in adult BCR-ABL1–negative B-ALL

E Paietta, KG Roberts, V Wang, Z Gu… - Blood, The Journal …, 2021 - ashpublications.org
Genomic classification has improved risk assignment of pediatric, but not adult B-lineage
acute lymphoblastic leukemia (B-ALL). The international UKALLXII/ECOG-ACRIN E2993 (# …

Genomic and outcome analyses of Ph-like ALL in NCI standard-risk patients: a report from the Children's Oncology Group

KG Roberts, SC Reshmi, RC Harvey… - Blood, The Journal …, 2018 - ashpublications.org
Philadelphia chromosome–like acute lymphoblastic leukemia (Ph-like ALL; BCR-ABL1–like
ALL) in children with National Cancer Institute (NCI) intermediate-or high-risk (HR) ALL is …

Prognostic impact of chromosomal abnormalities and copy number alterations in adult B-cell precursor acute lymphoblastic leukaemia: a UKALL14 study

AV Moorman, E Barretta, ER Butler, EJ Ward… - Leukemia, 2022 - nature.com
Chromosomal abnormalities are established prognostic markers in adult ALL. We assessed
the prognostic impact of established chromosomal abnormalities and key copy number …

Clinical diagnostics and treatment strategies for Philadelphia chromosome–like acute lymphoblastic leukemia

RC Harvey, SK Tasian - Blood advances, 2020 - ashpublications.org
Philadelphia chromosome-like B-cell acute lymphoblastic leukemia (Ph-like ALL) accounts
for 15% to 30% of B-cell acute lymphoblastic leukemia in older children, adolescents, and …

Oncogenic role and therapeutic targeting of ABL-class and JAK-STAT activating kinase alterations in Ph-like ALL

KG Roberts, YL Yang, D Payne-Turner, W Lin… - Blood …, 2017 - ashpublications.org
New therapies for Philadelphia chromosome–like acute lymphoblastic leukemia (Ph-like
ALL) patients are urgently needed. The genetic landscape of Ph-like ALL is characterized by …

Philadelphia chromosome–like acute lymphoblastic leukemia

CH Pui, KG Roberts, JJ Yang, CG Mullighan - Clinical Lymphoma Myeloma …, 2017 - Elsevier
Philadelphia chromosome–like acute lymphoblastic leukemia (Ph-like ALL) is a recently
described B-cell precursor ALL with a gene expression profile and a high frequency of IKZF1 …

Philadelphia-like acute lymphoblastic leukemia is associated with minimal residual disease persistence and poor outcome. First report of the minimal residual disease …

S Chiaretti, M Messina, I Della Starza… - …, 2020 - pmc.ncbi.nlm.nih.gov
Early recognition of Philadelphia-like (Ph-like) acute lymphoblastic leukemia (ALL) cases
could impact on the management and outcome of this subset of B-lineage ALL. In order to …

Recent advances in managing acute lymphoblastic leukemia

DJ DeAngelo, E Jabbour, A Advani - American Society of Clinical …, 2020 - ascopubs.org
Acute lymphoblastic leukemia (ALL) is characterized by chromosomal translocations and
somatic mutations that lead to leukemogenesis. The incorporation of pediatric-type regimens …