Extracellular vesicles as tools and targets in therapy for diseases

MA Kumar, SK Baba, HQ Sadida… - Signal transduction and …, 2024 - nature.com
Extracellular vesicles (EVs) are nano-sized, membranous structures secreted into the
extracellular space. They exhibit diverse sizes, contents, and surface markers and are …

Context-specific regulation of extracellular vesicle biogenesis and cargo selection

AC Dixson, TR Dawson, D Di Vizio… - … Reviews Molecular Cell …, 2023 - nature.com
To coordinate, adapt and respond to biological signals, cells convey specific messages to
other cells. An important aspect of cell–cell communication involves secretion of molecules …

Extracellular vesicles and nanoparticles: emerging complexities

DK Jeppesen, Q Zhang, JL Franklin, RJ Coffey - Trends in Cell Biology, 2023 - cell.com
The study of extracellular vesicles (EVs) and nanoparticles (NPs) is rapidly expanding
because recent discoveries have revealed a much greater complexity and diversity than was …

Challenges and directions in studying cell–cell communication by extracellular vesicles

G van Niel, DRF Carter, A Clayton… - … reviews Molecular cell …, 2022 - nature.com
Extracellular vesicles (EVs) are increasingly recognized as important mediators of
intercellular communication. They have important roles in numerous physiological and …

Circulating tumor nucleic acids: biology, release mechanisms, and clinical relevance

P Stejskal, H Goodarzi, J Srovnal, M Hajdúch… - Molecular cancer, 2023 - Springer
Background Despite advances in early detection and therapies, cancer is still one of the
most common causes of death worldwide. Since each tumor is unique, there is a need to …

Extracellular vesicles: a rising star for therapeutics and drug delivery

S Du, Y Guan, A **e, Z Yan, S Gao, W Li, L Rao… - Journal of …, 2023 - Springer
Extracellular vesicles (EVs) are nano-sized, natural, cell-derived vesicles that contain the
same nucleic acids, proteins, and lipids as their source cells. Thus, they can serve as natural …

Exosome processing and characterization approaches for research and technology development

JJ Lai, ZL Chau, SY Chen, JJ Hill… - Advanced …, 2022 - Wiley Online Library
Exosomes are extracellular vesicles that share components of their parent cells and are
attractive in biotechnology and biomedical research as potential disease biomarkers as well …

Exploiting the biogenesis of extracellular vesicles for bioengineering and therapeutic cargo loading

J Rädler, D Gupta, A Zickler, SEL Andaloussi - Molecular Therapy, 2023 - cell.com
Extracellular vesicles (EVs) are gaining increasing attention for diagnostic and therapeutic
applications in various diseases. These natural nanoparticles benefit from favorable safety …

Tumor-derived extracellular vesicles: multifunctional entities in the tumor microenvironment

JW Clancy, C D'Souza-Schorey - Annual Review of Pathology …, 2023 - annualreviews.org
Tumor cells release extracellular vesicles (EVs) that can function as mediators of
intercellular communication in the tumor microenvironment. EVs contain a host of bioactive …

Shedding light on extracellular vesicle biogenesis and bioengineering

F Teng, M Fussenegger - Advanced Science, 2021 - Wiley Online Library
Extracellular vesicles (EVs) are biocompatible, nano‐sized secreted vesicles containing
many types of biomolecules, including proteins, RNAs, DNAs, lipids, and metabolites. Their …