Collagen is a ubiquitous biomaterial in vertebrate animals. Although each of its 28 subtypes
contributes to the functions of many different tissues in the body, most studies on collagen or …

Osteoarthritis (OA) is a common degenerative joint disease characterized by cartilage
degradation, synovitis, subchondral bone sclerosis and osteophyte formation. Current …

Articular cartilage has poor ability to heal once damaged. Tissue engineering with scaffolds
of polymer hydrogels is promising for cartilage regeneration and repair. Polymer hydrogels …

Osteoarthritis (OA) represents a final and common pathway for all major traumatic insults to
synovial joints. OA is the most common form of degenerative joint disease and a major …

The differentiation and growth of adult stem cells within engineered tissue constructs are
hypothesized to be influenced by cell-biomaterial interactions. In this study, we compared …

Articular cartilage repair and regeneration continue to be largely intractable because of the
poor regenerative properties of this tissue. The field of articular cartilage tissue engineering …

Over the last two decades, considerable progress has been reported in the field of cartilage
mechanics that impacts our understanding of the role of interstitial fluid pressurization on …

Cartilage is a soft connective tissue that is composed of a single cell type, chondrocyte, and
a highly specialized extracellular matrix (ECM). Three major types of cartilaginous tissues …

Background Altered gait patterns follow ing anterior cruciate ligament reconstruction (ACLR)
may be associated with long-term impairments and post-traumatic osteoarthritis. Objective …

Extracellular matrix (ECM) components play essential roles in development, remodeling,
and signaling in the cardiovascular system. They are also important in determining the …