1, 3, 4-Thiadiazoles: A potent multi targeted pharmacological scaffold

S Haider, MS Alam, H Hamid - European journal of medicinal chemistry, 2015 - Elsevier
Despite a significant work on thiadiazoles, continuous efforts are still being made to identify
novel heterocyclic compounds with potent biological activities. This review may help the …

Synthesis and biological applications of triazole derivatives–a review

S Sathish Kumar, H P. Kavitha - Mini-Reviews in Organic …, 2013 - benthamdirect.com
There has been considerable interest in the development of novel heterocyclic compounds
with varied biological activities. Triazoles are a special class of heterocyclic compounds with …

Synthetic methods, chemistry, and the anticonvulsant activity of thiadiazoles

B Sharma, A Verma, S Prajapati… - International journal of …, 2013 - Wiley Online Library
The chemistry of heterocyclic compounds has been an interesting field of study for a long
time. Heterocyclic nucleus 1, 3, 4‐thiadiazole constitutes an important class of compounds …

Review on biological activities of 1, 3, 4-thiadiazole derivatives

G Mishra, K Jyoti - Journal of Applied Pharmaceutical Science, 2011 - japsonline.com
The Thiadiazole & their derivatives shown the number of pharmacological activity as anti
microbial, anti inflammatory activity, anti tubercular activity, ant diabetic activity, diuretics, anti …

Synthesis, biological evaluation and molecular docking studies of novel 1, 3, 4-thiadiazoles as potential anticancer agents and human carbonic anhydrase inhibitors

S Karakuş, E Başçıl, F Tok, Ö Erdoğan, Ö Çevik… - Molecular Diversity, 2023 - Springer
Abstract Thiosemicarbazide and also 1, 3, 4-thiadiazole derivatives have been garnering
substantial attention from researchers worldwide due to their expansive range of biological …

[PDF][PDF] Significance of nitrogen heterocyclic nuclei in the search of pharmacological active compounds

PK Shukla, A Verma, P Mishra - New perspective in agricultural …, 2017 - researchgate.net
Kee** this fact that study of body is biology but life is all about chemicals and chemical
transformations, many medicinal chemist start research in finding new and novel chemical …

[HTML][HTML] Synthetic transformations and medicinal significance of 1, 2, 3-thiadiazoles derivatives: An update

A Irfan, S Ullah, A Anum, N Jabeen, AF Zahoor… - Applied Sciences, 2021 - mdpi.com
The 1, 2, 3-thiadiazole moiety occupies a significant and prominent position among
privileged heterocyclic templates in the field of medicine, pharmacology and pharmaceutics …

Synthesis, molecular docking and anticancer activity of diflunisal derivatives as cyclooxygenase enzyme inhibitors

GP Coşkun, T Djikic, TB Hayal, N Türkel, K Yelekçi… - Molecules, 2018 - mdpi.com
Cyclooxygenase enzymes play a vital role in inflammatory pathways in the human body.
Apart from their relation with inflammation, the additional involvement of COX-2 enzyme with …

Anticancer and antimicrobial activities of some synthesized pyrazole and triazole derivatives.

WA El-Sayed, EM Flefel, EMH Morsy - 2012 - cabidigitallibrary.org
Abstract 5-[1-(Aryl)-5-phenyl-1H-pyrazol-3-yl]-4-phenyl-2, 4-dihydro [1, 2, 4] triazole-3-thione
derivatives 1a-c were reacted with chloropropanol, chloroacetone, chlorodiethyl ether and …

Synthesis of some novel 4-amino-4H-1,2,4-triazole-3-thiol derivatives

MM Khalaf, HMA El-Lateef, AA Amer… - Journal of the Iranian …, 2024 - Springer
A novel series of pyrazolyl [1, 2, 4] triazoles has been synthesized by the reaction of
polyfunctionalized-triazole 1 with symmetric and asymmetric β-dicarbonyl compounds in …