Respiration is a brain function on which our lives essentially depend. Control of respiration
ensures that the frequency and depth of breathing adapt continuously to metabolic needs. In …

▪ Abstract Breathing is a vital behavior that is particularly amenable to experimental
investigation. We review recent progress on three problems of broad interest.(i) Where and …

Opioid-induced respiratory depression (OIRD) represents the primary cause of death
associated with therapeutic and recreational opioid use. Within the United States, the rate of …

Neurokinin-1 receptor (NK1R) and μ-opioid receptor (μOR) agonists affected respiratory
rhythm when injected directly into the preBötzinger Complex (preBötC), the hypothesized …

The biochemical composition of the postsynaptic membrane and the structure of dendritic
spines may be rapidly modulated by synaptic activity. Here we review these findings …

Breathing is regulated automatically by neural circuits in the medulla to maintain
homeostasis, but breathing is also modified by behavior and emotion. Mice have rapid …

Are different forms of breathing derived from one or multiple neural networks? We
demonstrate that brainstem slices containing the pre-Bötzinger complex generated two …

Although recent evidence demonstrates considerable neuroplasticity in the respiratory
control system, a comprehensive conceptual framework is lacking. Our goals in this review …

Breathing is vital and must be concurrently robust and flexible. This rhythmic behavior is
generated and maintained within a rostrocaudally aligned set of medullary nuclei called the …

The regulation of breathing relies upon chemical feedback concerning the levels of CO2 and
O2. The carotid bodies, which detect O2, provide tonic excitation to brainstem respiratory …