Cytokine signaling represents one of the cornerstones of the immune system, mediating the
complex responses required to facilitate appropriate immune cell development and function …

The cytokine storm has captured the attention of the public and the scientific community
alike, and while the general notion of an excessive or uncontrolled release of …

Cytokine-inducible SH2-containing protein (CIS; encoded by the gene CISH) is a key
negative regulator of interleukin-15 (IL-15) signaling in natural killer (NK) cells. Here, we …

The use of omic modalities to dissect the molecular underpinnings of common diseases and
traits is becoming increasingly common. But multi-omic traits can be genetically predicted …

Recent genome-wide studies have reported novel associations between common
polymorphisms and susceptibility to many major infectious diseases in humans. In parallel …

Cytokines are key modulators of immunity. Most cytokines use the Janus kinase and signal
transducers and activators of transcription (JAK-STAT) pathway to promote gene …

Improving the functional avidity of effector T cells is critical in overcoming inhibitory factors
within the tumor microenvironment and eliciting tumor regression. We have found that Cish …

Background Disease risk and incidence between males and females reveal differences, and
sex is an important component of any investigation of the determinants of phenotypes or …

Cytokine and growth factor signaling mediates essential roles in the differentiation,
proliferation, survival and function of a number of cell lineages. This is achieved via specific …

Background. Mycobacterium tuberculosis can grow in the hostile intracellular environment of
macrophages by actively evading macrophage-associated antibacterial activities. The stress …