Obesity, inflammation, and immune system in osteoarthritis

U Nedunchezhiyan, I Varughese, ARJ Sun… - Frontiers in …, 2022 - frontiersin.org
Obesity remains the most important risk factor for the incidence and progression of
osteoarthritis (OA). The leading cause of OA was believed to be overloading the joints due to …

Obese visceral fat tissue inflammation: from protective to detrimental?

H Kolb - BMC medicine, 2022 - Springer
Obesity usually is accompanied by inflammation of fat tissue, with a prominent role of
visceral fat. Chronic inflammation in obese fat tissue is of a lower grade than acute immune …

Metabolic inflammation and insulin resistance in obesity

H Wu, CM Ballantyne - Circulation research, 2020 - ahajournals.org
Obesity is becoming an epidemic in the United States and worldwide and increases risk for
many diseases, particularly insulin resistance, type 2 diabetes mellitus, and cardiovascular …

Obesity and diabetes as high‐risk factors for severe coronavirus disease 2019 (Covid‐19)

Y Zhou, J Chi, W Lv, Y Wang - Diabetes/metabolism research …, 2021 - Wiley Online Library
The outbreak of the coronavirus disease 2019 (Covid‐19) has become an evolving
worldwide health crisis. With the rising prevalence of obesity and diabetes has come an …

Adipose tissue inflammation and metabolic dysfunction in obesity

T Kawai, MV Autieri, R Scalia - American Journal of …, 2021 - journals.physiology.org
Several lines of preclinical and clinical research have confirmed that chronic low-grade
inflammation of adipose tissue is mechanistically linked to metabolic disease and organ …

Adipokine dysregulation and adipose tissue inflammation in human obesity

X Unamuno, J Gómez‐Ambrosi… - European journal of …, 2018 - Wiley Online Library
Obesity, a worldwide epidemic, confers increased risk for multiple serious conditions,
including type 2 diabetes, cardiovascular diseases, nonalcoholic fatty liver disease and …

[HTML][HTML] Plasticity of epididymal adipose tissue in response to diet-induced obesity at single-nucleus resolution

AK Sárvári, EL Van Hauwaert, LK Markussen… - Cell metabolism, 2021 - cell.com
Adipose tissues display a remarkable ability to adapt to the dietary status. Here, we have
applied single-nucleus RNA-seq to map the plasticity of mouse epididymal white adipose …

Contribution of adipose tissue inflammation to the development of type 2 diabetes mellitus

MS Burhans, DK Hagman, JN Kuzma… - Comprehensive …, 2018 - pmc.ncbi.nlm.nih.gov
The objective of this comprehensive review is to summarize and discuss the available
evidence of how adipose tissue inflammation affects insulin sensitivity and glucose …

[HTML][HTML] The mechanism behind influenza virus cytokine storm

Y Gu, X Zuo, S Zhang, Z Ouyang, S Jiang, F Wang… - Viruses, 2021 - mdpi.com
Influenza viruses are still a serious threat to human health. Cytokines are essential for cell-to-
cell communication and viral clearance in the immune system, but excessive cytokines can …

Obesity-associated microbiomes instigate visceral adipose tissue inflammation by recruitment of distinct neutrophils

D Shantaram, R Hoyd, AM Blaszczak, L Antwi… - Nature …, 2024 - nature.com
Neutrophils are increasingly implicated in chronic inflammation and metabolic disorders.
Here, we show that visceral adipose tissue (VAT) from individuals with obesity contains …