[HTML][HTML] Pharmacological, neural, and psychological mechanisms underlying psychedelics: A critical review

M van Elk, DB Yaden - Neuroscience & Biobehavioral Reviews, 2022 - Elsevier
This paper provides a critical review of several possible mechanisms at different levels of
analysis underlying the effects and therapeutic potential of psychedelics. At the (1) …

Models of psychedelic drug action: modulation of cortical-subcortical circuits

MK Doss, MB Madden, A Gaddis, MB Nebel… - Brain, 2022 - academic.oup.com
Classic psychedelic drugs such as psilocybin and lysergic acid diethylamide (LSD) have
recaptured the imagination of both science and popular culture, and may have efficacy in …

Psychedelics in psychiatry: neuroplastic, immunomodulatory, and neurotransmitter mechanisms

A Inserra, D De Gregorio, G Gobbi, M Nader - Pharmacological Reviews, 2021 - Elsevier
Mounting evidence suggests safety and efficacy of psychedelic compounds as potential
novel therapeutics in psychiatry. Ketamine has been approved by the Food and Drug …

Emotions and brain function are altered up to one month after a single high dose of psilocybin

FS Barrett, MK Doss, ND Sepeda, JJ Pekar… - Scientific reports, 2020 - nature.com
Psilocybin is a classic psychedelic compound that may have efficacy for the treatment of
mood and substance use disorders. Acute psilocybin effects include reduced negative …

Clinically relevant acute subjective effects of psychedelics beyond mystical experience

DB Yaden, SP Goldy, B Weiss… - Nature Reviews …, 2024 - nature.com
The administration of classic psychedelics has been associated with well-being and mental
health benefits as well as risks and adverse events. The acute subjective effects of …

Spontaneous and deliberate creative cognition during and after psilocybin exposure

NL Mason, KPC Kuypers, JT Reckweg, F Müller… - Translational …, 2021 - nature.com
Creativity is an essential cognitive ability linked to all areas of our everyday functioning.
Thus, finding a way to enhance it is of broad interest. A large number of anecdotal reports …

[HTML][HTML] Psilocybin acutely alters the functional connectivity of the claustrum with brain networks that support perception, memory, and attention

FS Barrett, SR Krimmel, RR Griffiths, DA Seminowicz… - Neuroimage, 2020 - Elsevier
Psychedelic drugs, including the serotonin 2a (5-HT 2A) receptor partial agonist psilocybin,
are receiving renewed attention for their possible efficacy in treating a variety of …

How does psilocybin therapy work? An exploration of experiential avoidance as a putative mechanism of change

RJ Zeifman, AC Wagner, CM Monson… - Journal of Affective …, 2023 - Elsevier
Background Psilocybin therapy is receiving attention as a mental health intervention with
transdiagnostic potential. In line with psychotherapeutic research, qualitative research has …

Optimal dosing for psilocybin pharmacotherapy: Considering weight-adjusted and fixed dosing approaches

A Garcia-Romeu, FS Barrett… - Journal of …, 2021 - journals.sagepub.com
Background: Growing evidence suggests psilocybin, a naturally occurring psychedelic, is a
safe and promising pharmacotherapy for treatment of mood and substance use disorders …

Psilocybin's effects on cognition and creativity: A sco** review

JN Bonnieux, B VanderZwaag… - Journal of …, 2023 - journals.sagepub.com
Background: Research on psilocybin has become increasingly popular during the current
psychedelic renaissance, which began in the early 1990s. Psilocybin's effects on mental …