Organelle transport is vital for the development and maintenance of axons, in which the
distances between sites of organelle biogenesis, function, and recycling or degradation can …

The mitotic spindle uses microtubule-based motor proteins to assemble itself and to
segregate sister chromatids. It is becoming clear that motors invoke several distinct …

Summary The mTOR Complex 1 (mTORC1) pathway regulates cell growth in response to
numerous cues, including amino acids, which promote mTORC1 translocation to the …

To address questions about mechanisms of filament-based organelle transport, a system
was developed to image and track mitochondria in an intact Drosophila nervous system …

We tested whether proteins implicated in Huntington's and other polyglutamine (polyQ)
expansion diseases can cause axonal transport defects. Reduction of Drosophila huntingtin …

The large size and extreme polarization of neurons is crucial to their ability to communicate
at long distances and to form the complex cellular networks of the nervous system. The size …

We analyzed the mechanism of axonal transport of the amyloid precursor protein (APP),
which plays a major role in the development of Alzheimer's disease. Coimmunoprecipitation …

We tested the hypothesis that amyloid precursor protein (APP) and its relatives function as
vesicular receptor proteins for kinesin-I. Deletion of the Drosophila APP-like gene (Appl) or …

In axons, organelles move away from (anterograde) and toward (retrograde) the cell body
along microtubules. Previous studies have provided compelling evidence that conventional …

Cytoplasmic dyneins, the principal microtubule minus-end-directed motor proteins of the
cell, are involved in many essential cellular processes. The major form of this enzyme is a …