Modern classification of the family of human small heat shock proteins (the so-called HSPB)
is presented, and the structure and properties of three members of this family are analyzed …

Cataract can be defined as any opacity of the crystalline lens. Congenital cataract is
particularly serious because it has the potential for inhibiting visual development, resulting in …

Small heat-shock proteins (sHsps) are a diverse family of intra-cellular molecular chaperone
proteins that play a critical role in mitigating and preventing protein aggregation under stress …

The crystallins were discovered more than 100 years ago by Mörner (1893. Untersuchungen
der Proteinsubstanzen in den lichtbrechenden Medien des Auges. Z. Physiol. Chem. 18, 61 …

The eye lens is constantly subjected to oxidative stress from radiation and other sources.
The lens has several mechanisms to protect its components from oxidative stress and to …

Congenital cataracts, the most common cause of visual impairment and blindness in
children worldwide, have diverse etiologies. According to statistics analysis, about one …

Small heat shock proteins (sHSPs) are ATP-independent chaperones that delay formation of
harmful protein aggregates. sHSPs' role in protein homeostasis has been appreciated for …

Congenital cataracts are a significant cause of lifelong visual loss. They may be isolated or
associated with microcornea, microphthalmia, anterior segment dysgenesis (ASD) and …

Intermediate filaments (IFs) are a key component of the cytoskeleton in virtually all vertebrate
cells, including those of the lens of the eye. IFs help integrate individual cells into their …

Congenital cataracts are one of the most treatable causes of visual impairment and
blindness during infancy, with an estimated prevalence of 1 to 6 cases per 10,000 live births …