Astrocytes have long been regarded as essentially unexcitable cells that do not contribute to
active signaling and information processing in the brain. Contrary to this classical view, it is …

Epilepsy comprises a group of disorders characterized by the periodic occurrence of
seizures. Currently available anticonvulsant drugs and therapies are insufficient to …

Microglia are the main immune cells in the brain and have roles in brain homeostasis and
neurological diseases. Mechanisms underlying microglia–neuron communication remain …

BACKGROUND: The cystine-glutamate exchanger is downregulated after chronic cocaine,
resulting in reduced extracellular levels of nucleus accumbens glutamate. The importance of …

Astrocytes are critical participants in synapse development and function, but their role in
synaptic plasticity is unclear. Eph receptors and their ephrin ligands have been suggested to …

Voltage-gated potassium (Kv) channels are widely expressed in the central and peripheral
nervous system and are crucial mediators of neuronal excitability. Importantly, these …

Astrocytes express a plethora of ion channels, neurotransmitter receptors and transporters
and thus are endowed with the machinery to sense and respond to neuronal activity. Recent …

Junctions between cortical endoplasmic reticulum (cER) and the plasma membrane are a
subtle but ubiquitous feature in mammalian cells; however, very little is known about the …

Cerebral ischemia is a devastating condition that results in impaired blood flow in the brain
leading to acute brain injury. As the most common form of stroke, occlusion of cerebral …

Glutamate uptake is a process mediated by sodium-dependent glutamate transporters,
preventing glutamate spillover from the synapse. Typically, astrocytes express higher …