Glycoconjugates are major constituents of mammalian cells that are formed via covalent
conjugation of carbohydrates to other biomolecules like proteins and lipids and often …

The formation of well-defined protein bioconjugates is critical for many studies and
technologies in chemical biology. Tried-and-true methods for accomplishing this typically …

The growing interest in proteins, both in fundamental research and in drug discovery, has
fuelled demand for efficient synthetic methods to access these biomolecules. Although solid …

The study of biomolecules in their native environments is a challenging task because of the
vast complexity of cellular systems. Technologies developed in the last few years for the …

Nanobodies can be seen as next‐generation tools for the recognition and modulation of
antigens that are inaccessible to conventional antibodies. Due to their compact structure and …

Methods for site-specific modification of proteins should be quantitative and versatile with
respect to the nature and size of the biological or chemical targets involved. They should …

Caged compounds are light-sensitive probes that functionally encapsulate biomolecules in
an inactive form. Irradiation liberates the trapped molecule, permitting targeted perturbation …

Designer amino acids, beyond the canonical 20 that are normally used by cells, can now be
site-specifically encoded into proteins in cells and organisms. This is achieved …

The process of protein crosslinking comprises the chemical, enzymatic, or chemoenzymatic
formation of new covalent bonds between polypeptides. This allows (1) the site-directed …

Numerous post-translational modifications of histones have been described in organisms
ranging from yeast to humans. Growing evidence for dynamic regulation of these …