Skeletal muscle is able not only to increase its mass as an adaptation to mechanical loading
generated by and imposed upon muscle but also to regenerate after damage, via its intrinsic …

Osteosarcoma is the most common primary malignant tumor of the skeleton in teenagers
and young adults and continues to confer a generally poor prognosis in patients who do not …

Osteosarcoma is the most common bone sarcoma, which mainly affects adolescents and
young adults. Although the combination of modern surgery and systemic chemotherapy has …

Bisphosphonates are analogues of pyrophosphate, a key physicochemical inhibitor of
mineralisation. We examined the direct actions of bisphosphonates on the function of …

Summary Transforming Growth Factor β1 (TGF β1) exerts its functions both during
embryogenesis, and in adult organism. TGF β1 regulates cell proliferation, differentiation …

Abstract Insulinlike growth factor-1 (IGF-1) expression is implicated in myocardial
pathophysiology, and two IGF-1 mRNA splice variants have been detected in rodents, IGF …

Zoledronic acid (ZOL) has been shown to reduce osteolysis in bone metastasis. Its efficacy
in osteosarcoma has not been convincingly proved in a clinically relevant model for the …

Objectives The study objective was to evaluate the effect on osteoblast growth of high
concentrations of three nitrogen-containing bisphosphonates (pamidronate, alendronate …

Bisphosphonates (BPs) are widely used to treat bone diseases and also appear to possess
direct antitumour activity. We have previously reported that third-generation BPs such as …

Background: Osteosarcoma is considered the most frequent primary bone malignancy. Lung
metastasis is the leading cause of death and the most consistent factor for predicting …