The endothelium can evoke relaxations of the underlying vascular smooth muscle, by
releasing vasodilator substances. The best‐characterized endothelium‐derived relaxing …

Epidermal growth factor receptor (EGFR) activation impacts the physiology and
pathophysiology of the cardiovascular system, and inhibition of EGFR activity is emerging as …

Rationale: 20-Hydroxyeicosatetraenoic acid (20-HETE), one of the principle cytochrome
P450 eicosanoids, is a potent vasoactive lipid whose vascular effects include stimulation of …

hydroxyeicosatetraenoic acid (20-HETE) is a metabolite of arachidonic acid that exhibits a
myriad of biological effects in the vascular system. This review discusses the current …

Hydroxy-5, 8, 11, 14-eicosatetraenoic acid (20-HETE) is a cytochrome P450 (CYP)–derived
omega-hydroxylation metabolite of arachidonic acid. 20-HETE has been shown to play a …

The cytochrome P450 monooxygenase system (CYP) is a multigene superfamily of
enzymes, which are important in the metabolism of foreign and endogenous compounds …

HETE, the ω-hydroxylation product of arachidonic acid catalyzed by enzymes of the
cytochrome P450 (CYP) 4A and 4F gene families, is a bioactive lipid mediator with potent …

Arachidonic acid can be metabolized in blood vessels by three primary enzymatic pathways;
cyclooxygenase (COX), lipoxygenase (LO), and cytochrome P450 (CYP). These eicosanoid …

Thirty-five years ago, a third pathway for the metabolism of arachidonic acid by cytochrome
P450 enzymes emerged. Subsequent work revealed that 20-hydroxyeicosatetraenoic and …

Endothelial and vascular smooth cells generate cytochrome P450 (CYP) arachidonic acid
metabolites that can impact endothelial cell function and vascular homeostasis. The …