Clinical development of metal complexes as photosensitizers for photodynamic therapy of cancer

J Karges - Angewandte chemie international edition, 2022 - Wiley Online Library
Cancer has emerged over the last decades as one of the deadliest diseases in the world.
Among the most commonly used techniques (ie surgery, immunotherapy, radiotherapy or …

Luminescent and photofunctional transition metal complexes: From molecular design to diagnostic and therapeutic applications

LCC Lee, KKW Lo - Journal of the American Chemical Society, 2022 - ACS Publications
There has been emerging interest in the exploitation of the photophysical and
photochemical properties of transition metal complexes for diagnostic and therapeutic …

Theranostic imaging and multimodal photodynamic therapy and immunotherapy using the mTOR signaling pathway

H Zhou, D Tang, Y Yu, L Zhang, B Wang… - Nature …, 2023 - nature.com
Tumor metastases are considered the leading cause of cancer-associated deaths. While
clinically applied drugs have demonstrated to efficiently remove the primary tumor …

Targeting drug delivery with light: A highly focused approach

TL Rapp, CA DeForest - Advanced drug delivery reviews, 2021 - Elsevier
Light is a uniquely powerful tool for controlling molecular events in biology. No other
external input (eg, heat, ultrasound, magnetic field) can be so tightly focused or so highly …

A photoactivated sorafenib-ruthenium (II) prodrug for resistant hepatocellular carcinoma therapy through ferroptosis and purine metabolism disruption

Y Lai, N Lu, S Luo, H Wang… - Journal of Medicinal …, 2022 - ACS Publications
The curative effect of sorafenib in hepatocellular carcinoma (HCC) is limited and sorafenib
resistance remains a major obstacle for HCC. To overcome this obstacle, a new photoactive …

Hypoxia-activated NIR photosensitizer anchoring in the mitochondria for photodynamic therapy

F Xu, H Li, Q Yao, H Ge, J Fan, W Sun, J Wang… - Chemical …, 2019 - pubs.rsc.org
Photodynamic therapy is considered as a promising treatment for cancer, but still faces
several challenges. The hypoxic environment in solid tumors, imprecise tumor recognition …

Intraligand excited states turn a ruthenium oligothiophene complex into a light-triggered Ubertoxin with anticancer effects in extreme hypoxia

JA Roque III, HD Cole, PC Barrett… - Journal of the …, 2022 - ACS Publications
Ru (II) complexes that undergo photosubstitution reactions from triplet metal-centered (3MC)
excited states are of interest in photochemotherapy (PCT) due to their potential to produce …

Boron dipyrromethene nano‐photosensitizers for anticancer phototherapies

W Sun, X Zhao, J Fan, J Du, X Peng - Small, 2019 - Wiley Online Library
As traditional phototherapy agents, boron dipyrromethene (BODIPY) photosensitizers have
attracted increasing attention due to their high molar extinction coefficients, high …

Encapsulation of Ru (II) polypyridine complexes for tumor-targeted anticancer therapy

J Karges - BME frontiers, 2023 - spj.science.org
Ru (II) polypyridine complexes have attracted much attention as anticancer agents because
of their unique photophysical, photochemical, and biological properties. Despite their …

Photo-uncaging of a microtubule-targeted rigidin analogue in hypoxic cancer cells and in a xenograft mouse model

VHS van Rixel, V Ramu, AB Auyeung… - Journal of the …, 2019 - ACS Publications
Marine alkaloid rigidins are cytotoxic compounds known to kill cancer cells at nanomolar
concentrations by targeting the microtubule network. Here, a rigidin analogue containing a …