AI on a chip

A Isozaki, J Harmon, Y Zhou, S Li, Y Nakagawa… - Lab on a Chip, 2020 - pubs.rsc.org
Artificial intelligence (AI) has dramatically changed the landscape of science, industry,
defence, and medicine in the last several years. Supported by considerably enhanced …

Quantitative phase imaging trends in biomedical applications

T Cacace, V Bianco, P Ferraro - Optics and Lasers in Engineering, 2020 - Elsevier
In the last decades, the understanding of the complex biological mechanisms that regulate
the life and growth of single cells and their reciprocal interaction has steadily increased. In …

Stain-free identification of cell nuclei using tomographic phase microscopy in flow cytometry

D Pirone, J Lim, F Merola, L Miccio, M Mugnano… - Nature …, 2022 - nature.com
Quantitative phase imaging has gained popularity in bioimaging because it can avoid the
need for cell staining, which, in some cases, is difficult or impossible. However, as a result …

AI-driven projection tomography with multicore fibre-optic cell rotation

J Sun, B Yang, N Koukourakis, J Guck… - Nature …, 2024 - nature.com
Optical tomography has emerged as a non-invasive imaging method, providing three-
dimensional insights into subcellular structures and thereby enabling a deeper …

Speeding up reconstruction of 3D tomograms in holographic flow cytometry via deep learning

D Pirone, D Sirico, L Miccio, V Bianco, M Mugnano… - Lab on a Chip, 2022 - pubs.rsc.org
Tomographic flow cytometry by digital holography is an emerging imaging modality capable
of collecting multiple views of moving and rotating cells with the aim of recovering their …

Perspectives on liquid biopsy for label‐free detection of “circulating tumor cells” through intelligent lab‐on‐chips

L Miccio, F Cimmino, I Kurelac, MM Villone, V Bianco… - View, 2020 - Wiley Online Library
Circulating tumor cells (CTCs) are rare tumor cells released from primary, metastatic, or
recurrent tumors in the peripheral blood of cancer patients. CTCs isolation from peripheral …

Neuromorphic-enabled video-activated cell sorting

W He, J Zhu, Y Feng, F Liang, K You, H Chai… - Nature …, 2024 - nature.com
Imaging flow cytometry allows image-activated cell sorting (IACS) with enhanced feature
dimensions in cellular morphology, structure, and composition. However, existing IACS …

Polarization-sensitive optical diffraction tomography

A Saba, J Lim, AB Ayoub, EE Antoine, D Psaltis - Optica, 2021 - opg.optica.org
Polarization of light has been widely used as a contrast mechanism in two-dimensional (2D)
microscopy and also in some three-dimensional (3D) imaging modalities. In this paper, we …

Tomographic imaging flow cytometry

A Kleiber, D Kraus, T Henkel, W Fritzsche - Lab on a Chip, 2021 - pubs.rsc.org
Within the last decades, conventional flow cytometry (FC) has evolved as a powerful
measurement method in clinical diagnostics, biology, life sciences and healthcare. Imaging …

Three-dimensional quantitative intracellular visualization of graphene oxide nanoparticles by tomographic flow cytometry

D Pirone, M Mugnano, P Memmolo, F Merola… - Nano Letters, 2021 - ACS Publications
Interaction of nanoparticles (NPs) with cells is of fundamental importance in biology and
biomedical sciences. NPs can be taken up by cells, thus interacting with their intracellular …