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Expanding the plant genome editing toolbox with recently developed CRISPR–Cas systems
Since its first appearance, CRISPR–Cas9 has been developed extensively as a
programmable genome-editing tool, opening a new era in plant genome engineering …
programmable genome-editing tool, opening a new era in plant genome engineering …
CRISPR-based genome editing tools: an accelerator in crop breeding for a changing future
Genome editing is an important strategy to maintain global food security and achieve
sustainable agricultural development. Among all genome editing tools, CRISPR-Cas is …
sustainable agricultural development. Among all genome editing tools, CRISPR-Cas is …
Structure and genome editing of type IB CRISPR-Cas
M Lu, C Yu, Y Zhang, W Ju, Z Ye, C Hua, J Mao… - Nature …, 2024 - nature.com
Abstract Type I CRISPR-Cas systems employ multi-subunit effector Cascade and helicase-
nuclease Cas3 to target and degrade foreign nucleic acids, representing the most abundant …
nuclease Cas3 to target and degrade foreign nucleic acids, representing the most abundant …
RNA targeting and cleavage by the type III-Dv CRISPR effector complex
CRISPR-Cas are adaptive immune systems in bacteria and archaea that utilize CRISPR
RNA-guided surveillance complexes to target complementary RNA or DNA for destruction …
RNA-guided surveillance complexes to target complementary RNA or DNA for destruction …
Allosteric control of type IA CRISPR-Cas3 complexes and establishment as effective nucleic acid detection and human genome editing tools
Summary Type I CRISPR-Cas systems typically rely on a two-step process to degrade DNA.
First, an RNA-guided complex named Cascade identifies the complementary DNA target …
First, an RNA-guided complex named Cascade identifies the complementary DNA target …
Cas11 enables genome engineering in human cells with compact CRISPR-Cas3 systems
Leading CRISPR-Cas technologies employ Cas9 and Cas12 enzymes that generate RNA-
guided dsDNA breaks. Yet, the most abundant microbial adaptive immune systems, Type I …
guided dsDNA breaks. Yet, the most abundant microbial adaptive immune systems, Type I …
Discovery and characterization of novel type ID CRISPR-guided transposons identified among diverse Tn7-like elements in cyanobacteria
CRISPR-Cas defense systems have been naturally coopted for guide RNA-directed
transposition by Tn7 family bacterial transposons. We find cyanobacterial genomes are rich …
transposition by Tn7 family bacterial transposons. We find cyanobacterial genomes are rich …
[HTML][HTML] Exploiting activation and inactivation mechanisms in type IC CRISPR-Cas3 for genome-editing applications
Summary Type I CRISPR-Cas systems utilize the RNA-guided Cascade complex to identify
matching DNA targets and the nuclease-helicase Cas3 to degrade them. Among the seven …
matching DNA targets and the nuclease-helicase Cas3 to degrade them. Among the seven …
Structural rearrangements allow nucleic acid discrimination by type ID Cascade
CRISPR-Cas systems are adaptive immune systems that protect prokaryotes from foreign
nucleic acids, such as bacteriophages. Two of the most prevalent CRISPR-Cas systems …
nucleic acids, such as bacteriophages. Two of the most prevalent CRISPR-Cas systems …
[HTML][HTML] Molecular mechanism for Tn7-like transposon recruitment by a type IB CRISPR effector
Tn7-like transposons have co-opted CRISPR-Cas systems to facilitate the movement of their
own DNA. These CRISPR-associated transposons (CASTs) are promising tools for …
own DNA. These CRISPR-associated transposons (CASTs) are promising tools for …