The blood-brain barrier (BBB) prevents neurotoxic plasma components, blood cells, and
pathogens from entering the brain. At the same time, the BBB regulates transport of …

Adequate supply of blood and structural and functional integrity of blood vessels are key to
normal brain functioning. On the other hand, cerebral blood flow shortfalls and blood–brain …

Alzheimer disease (AD) is characterized by wide heterogeneity in cognitive and behavioural
syndromes, risk factors and pathophysiological mechanisms. Addressing this phenotypic …

AD is a neurodegenerative disease, and its frequency is often reported to be higher for
women than men: almost two-thirds of patients with AD are women. One prevailing view is …

Introduction The overall goal of the Alzheimer's Disease Neuroimaging Initiative (ADNI) is to
validate biomarkers for Alzheimer's disease (AD) clinical trials. ADNI is a multisite …

Alzheimer's disease (AD) manifests along a spectrum of cognitive deficits and levels of
neuropathology. Genetic studies support a heterogeneous disease mechanism, with around …

The blood–brain barrier (BBB) keeps neurotoxic plasma-derived components, cells, and
pathogens out of the brain. An early BBB breakdown and/or dysfunction have been shown in …

Abstract Apolipoprotein E4 (APOE4), the main susceptibility gene for Alzheimer's disease
(AD), leads to vascular dysfunction, amyloid-β pathology, neurodegeneration and dementia …

Exposure to particulate matter (PM) in the ambient air and its interactions with APOE alleles
may contribute to the acceleration of brain aging and the pathogenesis of Alzheimer's …

Men and women exhibit differences in the development and progression of Alzheimer's
disease (AD). The factors underlying the sex differences in AD are not well understood. This …