Importance Bipolar disorder affects approximately 8 million adults in the US and
approximately 40 million individuals worldwide. Observations Bipolar disorder is …

Uncertainty remains regarding the relative efficacy of maintenance pharmacotherapy for
bipolar disorder (BD), and available data require updating. The present systematic review …

Background: Bipolar disorder (BD) is a cyclic mood disorder characterised by alternating
episodes of mania/hypomania and depression interspersed with euthymic periods …

Background Bipolar disorder is a chronic mental disorder with repetitive mania/hypomania
as well as depressive episodes, which eventually results in marked impairment in overall …

Background Prophylactic treatment is critical for bipolar disorder (BD) patients. Valproate is
commonly used for this purpose but lacks regulatory approval and carries appreciable risks …

Abstract Background Bipolar Disorder (BD) represents the seventh major cause of disability
life-years-adjusted. Lithium remains as a first-line treatment, but clinical improvement occurs …

The plasma concentration of lamotrigine (LTG) and its metabolites has great interindividual
variability. An UHPLC-MS/MS method for simultaneous determination of LTG and …

Purpose The purpose of this study was to evaluate the effect of UGT1A4 and UGT2B7
polymorphisms on the plasma concentration of lamotrigine in Chinese patients with bipolar …

Objective To provide up‐to‐date clinical guidance on the efficacy of lamotrigine in bipolar
disorder (BD). Methods Eligible studies were identified during a systematic literature search …

Objective Therapeutic drug monitoring for lamotrigine is poorly documented in bipolar and
depressive disorders. In order to evaluate its use among French psychiatrists, we explored …