Antiseizure drugs (ASDs) prevent the occurrence of seizures; there is no evidence that they
have disease-modifying properties. In the more than 160 years that orally administered …

Developmental and epileptic encephalopathies (DEEs) are a heterogeneous group of
disorders characterized by early-onset, often severe epileptic seizures and EEG …

The trigeminal nerve (V) is the fifth and largest of all cranial nerves, and it is responsible for
detecting sensory stimuli that arise from the craniofacial area. The nerve is divided into three …

The emergence of OpenAI's ChatGPT has put intense spotlight on Generative AI (Gen-AI)
systems and their possible impacts on Academic integrity. This paper provides an overview …

Cannabis sativa contains many related compounds known as phytocannabinoids. The main
psychoactive and nonpsychoactive compounds are Δ9-tetrahydrocannabinol (THC) and …

Tetrodotoxin (TTX) is a potent neurotoxin responsible for many human intoxications and
fatalities each year. The origin of TTX is unknown, but in the pufferfish, it seems to be …

Voltage-gated sodium (Nav) channels are essential for the rapid depolarization of nerve and
muscle, and are important drug targets. Determination of the structures of Nav channels will …

The activity of voltage-gated sodium channels has long been linked to disorders of neuronal
excitability such as epilepsy and chronic pain. Recent genetic studies have now expanded …

Antiseizure drugs (ASDs), also termed antiepileptic drugs, are the main form of symptomatic
treatment for people with epilepsy, but not all patients become free of seizures. The …

Voltage-gated sodium channels initiate action potentials in nerve, skeletal muscle, and other
electrically excitable cells. Mutations in them cause a wide range of diseases. These …