Phytocannabinoids like∆ 9-tetrahydrocannabinol (THC) and cannabidiol (CBD) show a
beneficial effect on neuroinflammatory and neurodegenerative processes through cell …

Since ancient times, Cannabis and its preparations have found various applications such as
for medical, recreational and industrial purposes. Subsequently the 1930s, legislation in …

The organized, tightly regulated signaling relays engaged by the cannabinoid receptors
(CBs) and their ligands, G proteins and other effectors, together constitute the …

Cannabinoid type 2 receptor (CB2R) is an attractive target for the treatment of pain and
inflammatory disorders. Availability of a selective CB2R fluorescent ligand to study CB2R …

A combination of molecular modeling and structure–activity relationship studies has been
used to fine-tune CB2 selectivity in the chromenopyrazole ring, a versatile CB1/CB2 …

Designing drugs with a specific multi-target profile is a promising approach against
multifactorial illnesses as Alzheimer's disease. In this work, new indazole ethers that …

Single chemical entities with potential to simultaneously interact with two binding sites are
emerging strategies in medicinal chemistry. We have designed, synthesized and functionally …

Chromenopyrazolediones have been designed and synthesized as anticancer agents using
the multi-biological target concept that involves quinone cytotoxicity and cannabinoid …

Triple-negative breast cancer (TNBC) represents a subtype of breast cancer characterized
by high aggressiveness. There is no current targeted therapy for these patients whose …

The therapeutic use of Cannabis dates back to ancient times and this plant has been used
for centuries as remedy for a large number of diseases. Today it is well known that biological …