The JAK-STAT pathway at 30: Much learned, much more to do
The discovery of the Janus kinase (JAK)-signal transducer and activator of transcription
(STAT) pathway arose from investigations of how cells respond to interferons (IFNs) …
(STAT) pathway arose from investigations of how cells respond to interferons (IFNs) …
Diversity, mechanisms, and significance of macrophage plasticity
Macrophages are a diverse set of cells present in all body compartments. This diversity is
imprinted by their ontogenetic origin (embryonal versus adult bone marrow–derived cells); …
imprinted by their ontogenetic origin (embryonal versus adult bone marrow–derived cells); …
[HTML][HTML] A unique microglia type associated with restricting development of Alzheimer's disease
Alzheimer's disease (AD) is a detrimental neurodegenerative disease with no effective
treatments. Due to cellular heterogeneity, defining the roles of immune cell subsets in AD …
treatments. Due to cellular heterogeneity, defining the roles of immune cell subsets in AD …
Macrophage polarization
PJ Murray - Annual review of physiology, 2017 - annualreviews.org
Macrophage polarization refers to how macrophages have been activated at a given point in
space and time. Polarization is not fixed, as macrophages are sufficiently plastic to integrate …
space and time. Polarization is not fixed, as macrophages are sufficiently plastic to integrate …
Trained immunity: a program of innate immune memory in health and disease
BACKGROUND Host immune responses are classically divided into innate immune
responses, which react rapidly and nonspecifically upon encountering a pathogen, and …
responses, which react rapidly and nonspecifically upon encountering a pathogen, and …
[HTML][HTML] Chromatin potential identified by shared single-cell profiling of RNA and chromatin
Cell differentiation and function are regulated across multiple layers of gene regulation,
including modulation of gene expression by changes in chromatin accessibility. However …
including modulation of gene expression by changes in chromatin accessibility. However …
Challenges in unsupervised clustering of single-cell RNA-seq data
Single-cell RNA sequencing (scRNA-seq) allows researchers to collect large catalogues
detailing the transcriptomes of individual cells. Unsupervised clustering is of central …
detailing the transcriptomes of individual cells. Unsupervised clustering is of central …
Regulation of type I interferon responses
LB Ivashkiv, LT Donlin - Nature Reviews Immunology, 2014 - nature.com
Type I interferons (IFNs) activate intracellular antimicrobial programmes and influence the
development of innate and adaptive immune responses. Canonical type I IFN signalling …
development of innate and adaptive immune responses. Canonical type I IFN signalling …
From monocytes to M1/M2 macrophages: phenotypical vs. functional differentiation
Studies on monocyte and macrophage biology and differentiation have revealed the
pleiotropic activities of these cells. Macrophages are tissue sentinels that maintain tissue …
pleiotropic activities of these cells. Macrophages are tissue sentinels that maintain tissue …
[HTML][HTML] Tissue-resident macrophage enhancer landscapes are shaped by the local microenvironment
Macrophages are critical for innate immune defense and also control organ homeostasis in
a tissue-specific manner. They provide a fitting model to study the impact of ontogeny and …
a tissue-specific manner. They provide a fitting model to study the impact of ontogeny and …