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Recent advances in non-small cell lung cancer targeted therapy; an update review
Lung cancer continues to be the leading cause of cancer-related death worldwide. In the last
decade, significant advancements in the diagnosis and treatment of lung cancer, particularly …
decade, significant advancements in the diagnosis and treatment of lung cancer, particularly …
NTRK fusion-positive cancers and TRK inhibitor therapy
N TRK gene fusions involving either NTRK1, NTRK2 or NTRK3 (encoding the neurotrophin
receptors TRKA, TRKB and TRKC, respectively) are oncogenic drivers of various adult and …
receptors TRKA, TRKB and TRKC, respectively) are oncogenic drivers of various adult and …
Analysis of NTRK Alterations in Pan-Cancer Adult and Pediatric Malignancies: Implications for NTRK-Targeted Therapeutics
R Okamura, A Boichard, S Kato, JK Sicklick… - JCO precision …, 2018 - ascopubs.org
Purpose Fusions that involve neurotrophic-tropomyosin receptor kinase (NTRK) genes are
known drivers of oncogenesis. Therapies that target these ultra-rare, constitutionally active …
known drivers of oncogenesis. Therapies that target these ultra-rare, constitutionally active …
Functional biomaterials for bone regeneration: a lesson in complex biology
AR Armiento, LP Hatt… - Advanced Functional …, 2020 - Wiley Online Library
Bone is a hard yet dynamic tissue with remarkable healing capacities. Research to date has
greatly advanced the understanding of how bone heals and has led to marked success in …
greatly advanced the understanding of how bone heals and has led to marked success in …
TRKing down an old oncogene in a new era of targeted therapy
The use of high-throughput next-generation sequencing techniques in multiple tumor types
during the last few years has identified NTRK1, 2, and 3 gene rearrangements encoding …
during the last few years has identified NTRK1, 2, and 3 gene rearrangements encoding …
Drug resistance to targeted therapeutic strategies in non-small cell lung cancer
Rapidly develo** molecular biology techniques have been employed to identify cancer
driver genes in specimens from patients with non-small cell lung cancer (NSCLC). Inhibitors …
driver genes in specimens from patients with non-small cell lung cancer (NSCLC). Inhibitors …
Neurotrophic factors: an overview
SD Skaper - Neurotrophic Factors: Methods and Protocols, 2018 - Springer
The neurotrophins are a family of closely related proteins that were first identified as survival
factors for sympathetic and sensory neurons and have since been shown to control a …
factors for sympathetic and sensory neurons and have since been shown to control a …
Targeting TRK family proteins in cancer
The tropomyosin receptor kinase (TRK) family includes TRKA, TRKB, and TRKC proteins,
which are encoded by NTRK1, NTRK2 and NTRK3 genes, respectively. Binding of …
which are encoded by NTRK1, NTRK2 and NTRK3 genes, respectively. Binding of …
Mechanisms of cancer dissemination along nerves
The local extension of cancer cells along nerves is a frequent clinical finding for various
tumours. Traditionally, nerve invasion was assumed to occur via the path of least resistance; …
tumours. Traditionally, nerve invasion was assumed to occur via the path of least resistance; …
Trk receptors: roles in neuronal signal transduction
▪ Abstract Trk receptors are a family of three receptor tyrosine kinases, each of which can be
activated by one or more of four neurotrophins—nerve growth factor (NGF), brain-derived …
activated by one or more of four neurotrophins—nerve growth factor (NGF), brain-derived …