The fibroblast growth factor (FGF) family is composed of 18 secreted signaling proteins
consisting of canonical FGFs and endocrine FGFs that activate four receptor tyrosine …

Here we delineate the ontogeny of the mammalian endoderm by generating 112,217 single-
cell transcriptomes, which represent all endoderm populations within the mouse embryo …

Gastrulation is the process whereby cells exit pluripotency and concomitantly acquire and
pattern distinct cell fates. This is driven by the convergence of WNT, BMP, Nodal and FGF …

The prevailing dogma for morphological patterning in develo** organisms argues that the
combined inputs of transcription factor networks and signalling morphogens alone generate …

The anterior-posterior axis of the mammalian embryo is laid down by the anterior visceral
endoderm (AVE), an extraembryonic signaling center that is specified within the visceral …

Precise control and maintenance of population size is fundamental for organismal
development and homeostasis. The three cell types of the mammalian blastocyst are …

Primordial germ cells (PGCs) are the early embryonic precursors of gametes–sperm and
egg cells. PGC-like cells (PGCLCs) can currently be derived in vitro from pluripotent cells …

FGF/ERK signaling is crucial for the patterning and proliferation of cell lineages that
comprise the mouse blastocyst. However, ERK signaling dynamics have never been directly …

During embryonic development and tissue homeostasis, reproducible proportions of
differentiated cell types are specified from populations of multipotent precursor cells …

The blastocyst is a conserved stage and distinct milestone in the development of the
mammalian embryo. Blastocyst stage embryos comprise three cell lineages which arise …