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Establishment of H3K9-methylated heterochromatin and its functions in tissue differentiation and maintenance
Heterochromatin is characterized by dimethylated or trimethylated histone H3 Lys9
(H3K9me2 or H3K9me3, respectively) and is found at transposable elements, satellite …
(H3K9me2 or H3K9me3, respectively) and is found at transposable elements, satellite …
Interleukin-2 signaling in the regulation of T cell biology in autoimmunity and cancer
AN Shouse, KM LaPorte, TR Malek - Immunity, 2024 - cell.com
Summary Interleukin-2 (IL-2) is a critical cytokine for T cell peripheral tolerance and
immunity. Here, we review how IL-2 interaction with the high-affinity IL-2 receptor (IL-2R) …
immunity. Here, we review how IL-2 interaction with the high-affinity IL-2 receptor (IL-2R) …
Covid‐19 and oral diseases: Crosstalk, synergy or association?
Summary The coronavirus disease 2019 (Covid‐19) is a viral infection caused by severe
acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) that clinically affects multiple …
acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) that clinically affects multiple …
Th17 and regulatory T cell balance in autoimmune and inflammatory diseases
M Noack, P Miossec - Autoimmunity reviews, 2014 - Elsevier
This review focuses on the biology of T helper 17 (Th17) and regulatory T (Treg) cells and
their role in inflammatory diseases, such as rheumatoid arthritis. Th17 cells represent a pro …
their role in inflammatory diseases, such as rheumatoid arthritis. Th17 cells represent a pro …
Association of psoriasis with inflammatory bowel disease: a systematic review and meta-analysis
Importance Patients with psoriasis may experience comorbidities involving cardiovascular
diseases, chronic kidney disease, uveitis, psychiatric disturbances, and metabolic …
diseases, chronic kidney disease, uveitis, psychiatric disturbances, and metabolic …
Pro-regenerative biomaterials recruit immunoregulatory dendritic cells after traumatic injury
During wound healing and surgical implantation, the body establishes a delicate balance
between immune activation to fight off infection and clear debris and immune tolerance to …
between immune activation to fight off infection and clear debris and immune tolerance to …
NETs are a source of citrullinated autoantigens and stimulate inflammatory responses in rheumatoid arthritis
R Khandpur, C Carmona-Rivera… - Science translational …, 2013 - science.org
The early events leading to the development of rheumatoid arthritis (RA) remain unclear, but
formation of autoantibodies to citrullinated protein antigens (ACPAs) is considered a key …
formation of autoantibodies to citrullinated protein antigens (ACPAs) is considered a key …
CD4+ effector T cells accelerate Alzheimer's disease in mice
Background Alzheimer's disease (AD) is a progressive neurodegenerative disorder
characterized by pathological deposition of misfolded self-protein amyloid beta (Aβ) which in …
characterized by pathological deposition of misfolded self-protein amyloid beta (Aβ) which in …
The role of Th17 cells/IL-17A in AD, PD, ALS and the strategic therapy targeting on IL-17A
J Fu, Y Huang, T Bao, C Liu, X Liu, X Chen - Journal of Neuroinflammation, 2022 - Springer
Neurodegenerative diseases are a group of disorders characterized by progressive loss of
certain populations of neurons, which eventually lead to dysfunction. These diseases …
certain populations of neurons, which eventually lead to dysfunction. These diseases …
Cytokines in psoriasis
Psoriasis is a common inflammatory skin disease with an incompletely understood etiology.
The disease is characterized by red, scaly and well-demarcated skin lesions formed by the …
The disease is characterized by red, scaly and well-demarcated skin lesions formed by the …