Type 1 diabetes (T1D) results from immune‐mediated loss of pancreatic beta cells leading
to insulin deficiency. It is the most common form of diabetes in children, and its incidence is …

Type 1 diabetes (T1D) is an autoimmune disease that usually strikes early in life, but can
affect individuals at almost any age. It is caused by autoreactive T cells that destroy insulin …

Iterative advances in understanding of the genetics of type 1 diabetes have identified> 70
genetic regions associated with risk of the disease, including strong associations across the …

The endocrine pancreas is one of the most inaccessible organs of the human body. Its
autoimmune attack leads to type 1 diabetes (T1D) in a genetically susceptible population …

Type 1 diabetes mellitus (T1DM) is a chronic autoimmune condition characterized by the
irreversible destruction of the β cells of the pancreas, which leads to a lifelong dependency …

Abstract Type 1 diabetes (T1D) is a complex, chronic autoimmune disease that affects over
1.6 million people in the United States. It is now understood that T1D may be undetected for …

Abstract Purpose of Review We provide an overview of the current knowledge regarding the
natural history of human type 1 diabetes (T1D) and the documented associations between …

Abstract Background Diabetes Mellitus (DM), a chronic metabolic disease characterized by
elevated blood glucose, is caused by various degrees of insulin resistance and …

Type 1 diabetes mellitus (T1DM) is characterized by autoimmune destruction of pancreatic
beta-cells in genetically predisposed individuals, eventually resulting in severe insulin …

Autoimmune diseases are characterized by the irregular functioning of the immune system
that leads to the loss of tolerance to self-antigens. The underlying nature of autoimmune …