Skeletal muscle is a dynamic organ requiring tight regulation of energy metabolism in order
to provide bursts of energy for effective function. Several inborn errors of muscle energy …

Carbohydrate availability affects fat metabolism during exercise; however, the effects of
complete muscle glycogen unavailability on maximal fat oxidation (MFO) rate remain …

Glycogen storage disorders (GSDs) are a group of inherited metabolic disorders
characterized by defects in enzymes involved in glycogen metabolism. Deficiencies in …

Background & aims Ketone supplementation is gaining popularity. Yet, its effects on
exercise performance when muscle glycogen cannot be used remain to be determined …

We explored the association between aerobic capacity (AC) and the skeletal muscle
proteome of McArdle (n= 10) and wild‐type (n= 8) mice, as models of intrinsically 'low'and …

McArdle disease (glycogen storage disease type V; GSDV) is a rare genetic disease caused
by the inability to break down glycogen in skeletal muscle due to a deficiency in …

The practice of physical fitness training plays a crucial role in the management of McArdle
disease (MD), a metabolic myopathy characterized by myophosphorylase deficiency, which …

McArdle disease or glycogen storage disease Type V is a genetic condition caused by
PYGM gene mutations leading to exercise intolerance and fatigability. The condition most …

Background McArdle disease is caused by myophosphorylase deficiency and results in
complete inability for muscle glycogen breakdown. A hallmark of this condition is muscle …

Muscle glycogen unavailability and fat oxidation rate during exercise: Insights from McArdle
disease. Keywords: exercise; fat metabolism; glycogen; McArdle disease EN exercise fat …