Ethnobotany and the role of plant natural products in antibiotic drug discovery
The crisis of antibiotic resistance necessitates creative and innovative approaches, from
chemical identification and analysis to the assessment of bioactivity. Plant natural products …
chemical identification and analysis to the assessment of bioactivity. Plant natural products …
Ambient ionization mass spectrometry: recent developments and applications
The early 2000s brought a new age in the field of mass spectrometry (MS) with the
introduction of ambient ionization MS techniques. As defined by one of its early visionaries …
introduction of ambient ionization MS techniques. As defined by one of its early visionaries …
Spatially resolved multi-omics highlights cell-specific metabolic remodeling and interactions in gastric cancer
C Sun, A Wang, Y Zhou, P Chen, X Wang… - Nature …, 2023 - nature.com
Map** tumor metabolic remodeling and their spatial crosstalk with surrounding non-tumor
cells can fundamentally improve our understanding of tumor biology, facilitates the …
cells can fundamentally improve our understanding of tumor biology, facilitates the …
Nondestructive tissue analysis for ex vivo and in vivo cancer diagnosis using a handheld mass spectrometry system
Conventional methods for histopathologic tissue diagnosis are labor-and time-intensive and
can delay decision-making during diagnostic and therapeutic procedures. We report the …
can delay decision-making during diagnostic and therapeutic procedures. We report the …
Unsupervised machine learning for exploratory data analysis in imaging mass spectrometry
Imaging mass spectrometry (IMS) is a rapidly advancing molecular imaging modality that
can map the spatial distribution of molecules with high chemical specificity. IMS does not …
can map the spatial distribution of molecules with high chemical specificity. IMS does not …
Spatially resolved metabolomics to discover tumor-associated metabolic alterations
Characterization of tumor metabolism with spatial information contributes to our
understanding of complex cancer metabolic reprogramming, facilitating the discovery of …
understanding of complex cancer metabolic reprogramming, facilitating the discovery of …
Ion mobility mass spectrometry in the omics era: Challenges and opportunities for metabolomics and lipidomics
Researchers worldwide are taking advantage of novel, commercially available,
technologies, such as ion mobility mass spectrometry (IM‐MS), for metabolomics and …
technologies, such as ion mobility mass spectrometry (IM‐MS), for metabolomics and …
Mass spectrometry using electrospray ionization
GRD Prabhu, ER Williams, M Wilm… - Nature Reviews Methods …, 2023 - nature.com
Applying a high voltage to a liquid passing through a capillary disintegrates the liquid
meniscus to generate a fine spray of charged droplets. As the droplets evaporate, polar …
meniscus to generate a fine spray of charged droplets. As the droplets evaporate, polar …
Quantitative mass spectrometry imaging of biological systems
Mass spectrometry imaging (MSI) is a powerful, label-free technique that provides detailed
maps of hundreds of molecules in complex samples with high sensitivity and subcellular …
maps of hundreds of molecules in complex samples with high sensitivity and subcellular …
Advances in mass spectrometry-based metabolomics for investigation of metabolites
JL Ren, AH Zhang, L Kong, XJ Wang - RSC advances, 2018 - pubs.rsc.org
Metabolomics is the systematic study of all the metabolites present within a biological
system, which consists of a mass of molecules, having a variety of physical and chemical …
system, which consists of a mass of molecules, having a variety of physical and chemical …