It is now well established that the blood-clotting protein fibrinogen can polymerise into an
anomalous form of fibrin that is amyloid in character; the resultant clots and microclots entrap …

Synucleinopathies are a group of neurodegenerative disorders caused by the misfolding
and self-templating of the protein α-synuclein, or the formation of α-synuclein prions. Each …

Systemic ATTR amyloidosis is an increasingly important protein misfolding disease that is
provoked by the formation of amyloid fibrils from transthyretin protein. The pathological and …

An early and accurate in vivo diagnosis of rapidly progressive dementia remains
challenging, despite its critical importance for the outcome of treatable forms, and the …

Aβ plaques are one of the two lesions in the brain that define the neuropathological
diagnosis of Alzheimer's disease. Plaques are highly diverse structures; many of them …

Lewy body disorders (LBD), characterized by the deposition of misfolded α-synuclein (α-
Syn), are clinically heterogeneous. Although the distribution of α-Syn correlates with the …

Prion diseases are a group of inevitably fatal neurodegenerative disorders affecting
numerous mammalian species, including humans. The existence of heritable phenotypes of …

Synucleinopathies are a group of clinically and neuropathologically distinct protein
misfolding diseases caused by unique α-synuclein conformations, or strains. While multiple …

Prion diseases are a unique group of rare neurodegenerative disorders characterized by
tissue deposition of heterogeneous aggregates of abnormally folded protease-resistant …

Abstract α-synuclein (αSyn) is an intrinsically disordered protein which can undergo
structural transformations, resulting in the formation of stable, insoluble fibrils. αSyn amyloid …