While detailed analysis of aberrant cancer cell signaling pathways and changes in cancer
cell DNA has dominated the field of breast cancer biology for years, there now exists …

During different stages of tumor development the immune system can either identify and
destroy tumors, or promote their growth. Therapies targeting the immune system have …

Protein diversity due to alternative mRNA splicing or post-translational modifications (PTMs)
plays a vital role in various cellular functions. The mitotic kinases polo-like kinase 1 (PLK1) …

Survivin is a 16.5 kDa protein overexpressed in almost all malignancies but rarely detected
in normal differentiated adult tissues. Functionally, survivin has been shown to inhibit …

Human epidermal growth factor receptor 2 (HER2) expression in breast cancer is associated
with an aggressive phenotype and poor prognosis, making it an appealing therapeutic …

An increasing number of tumors, including breast cancer, overexpress proteins of the
epidermal growth factor receptor (EGFR) family. The interaction between family members …

INTRODUCTION: Survivin a multifunctional protein that controls cell division, inhibition of
apoptosis and promotion of angiogenesis. It is expressed in most human neoplasm, but is …

Background Triple-negative breast cancers represent an important clinical challenge, as
these cancers do not respond to conventional endocrine therapies or other available …

Since the discovery of survivin (BIRC5) as a cancer-related molecule by Grazia Ambrosini
and Dario C. Altieri at 1997, our knowledge related to the function of this molecule has been …

Purpose Colorectal cancer is one of the most common cancers worldwide. We tested the
hypothesis that differences in the expression of certain molecular markers of colon cancer …