H3K9me3-dependent heterochromatin: barrier to cell fate changes
Establishing and maintaining cell identity depends on the proper regulation of gene
expression, as specified by transcription factors and reinforced by epigenetic mechanisms …
expression, as specified by transcription factors and reinforced by epigenetic mechanisms …
Chromatin dynamics during cellular reprogramming
E Apostolou, K Hochedlinger - Nature, 2013 - nature.com
Induced pluripotency is a powerful tool to derive patient-specific stem cells. In addition, it
provides a unique assay to study the interplay between transcription factors and chromatin …
provides a unique assay to study the interplay between transcription factors and chromatin …
Deterministic direct reprogramming of somatic cells to pluripotency
Somatic cells can be inefficiently and stochastically reprogrammed into induced pluripotent
stem (iPS) cells by exogenous expression of Oct4 (also called Pou5f1), Sox2, Klf4 and Myc …
stem (iPS) cells by exogenous expression of Oct4 (also called Pou5f1), Sox2, Klf4 and Myc …
Chromatin repressive complexes in stem cells, development, and cancer
A Laugesen, K Helin - Cell stem cell, 2014 - cell.com
The chromatin environment is essential for the correct specification and preservation of cell
identity through modulation and maintenance of transcription patterns. Many chromatin …
identity through modulation and maintenance of transcription patterns. Many chromatin …
[HTML][HTML] Common stemness regulators of embryonic and cancer stem cells
C Hadjimichael, K Chanoumidou… - World journal of stem …, 2015 - ncbi.nlm.nih.gov
Pluripotency of embryonic stem cells (ESCs) and induced pluripotent stem cells is regulated
by a well characterized gene transcription circuitry. The circuitry is assembled by ESC …
by a well characterized gene transcription circuitry. The circuitry is assembled by ESC …
The let-7/LIN-41 pathway regulates reprogramming to human induced pluripotent stem cells by controlling expression of prodifferentiation genes
KA Worringer, TA Rand, Y Hayashi, S Sami… - Cell stem cell, 2014 - cell.com
Reprogramming differentiated cells into induced pluripotent stem cells (iPSCs) promotes a
broad array of cellular changes. Here we show that the let-7 family of microRNAs acts as an …
broad array of cellular changes. Here we show that the let-7 family of microRNAs acts as an …
The nucleosome remodeling and deacetylase complex in development and disease
J Basta, M Rauchman - Translating epigenetics to the clinic, 2017 - Elsevier
Abstract The Nucleosome Remodeling and Deacetylase (NuRD) complex is one of the
major chromatin remodeling complexes found in cells. It plays an important role in regulating …
major chromatin remodeling complexes found in cells. It plays an important role in regulating …
Molecular features of cellular reprogramming and development
ZD Smith, C Sindhu, A Meissner - Nature reviews Molecular cell biology, 2016 - nature.com
Differentiating somatic cells are progressively restricted to specialized functions during
ontogeny, but they can be experimentally directed to form other cell types, including those …
ontogeny, but they can be experimentally directed to form other cell types, including those …
Reprogramming of cell fate: epigenetic memory and the erasure of memories past
Cell identity is a reflection of a cell type‐specific gene expression profile, and consequently,
cell type‐specific transcription factor networks are considered to be at the heart of a given …
cell type‐specific transcription factor networks are considered to be at the heart of a given …
A NuRD for all seasons
The nucleosome-remodeling and deacetylase (NuRD) complex is an essential
transcriptional regulator in all complex animals. All seven core subunits of the complex exist …
transcriptional regulator in all complex animals. All seven core subunits of the complex exist …