The role of mitochondria as a nexus of developmental regulation in mammalian oogenesis
and early embryogenesis is emerging from basic research in model species and from …

Recent studies challenge the previous view that apoptosis within the granulosa cells of the
maturing ovarian follicle is a reflection of aging and consequently a marker for poor quality of …

Current treatments of subfertile couples are usually empiric, as the true cause of subfertility
often remains unknown. Therefore, we outline the role of nutritional and biochemical factors …

BACKGROUND In humans, normal healthy children are regularly produced through
fertilization of fresh oocytes with fresh spermatozoa. However, asynchrony between oocytes …

Mitochondria do not only produce less ATP, but they also increase the production of reactive
oxygen species (ROS) as byproducts of aerobic metabolism in the aging tissues of the …

It is well established that age-related decline of the biological capacity of a woman to
reproduce is primarily related to the poor developmental potential of her gametes. This …

With extended periods of time following ovulation, the metaphase II stage oocyte
experiences deterioration in quality referred to as post-ovulatory oocyte ageing. Post …

The present study was conducted to examine the protective effect of cumulus cells on oocyte
damage caused by reactive oxygen species (ROS), generated by the hypoxanthine …

Although the study of germ cell death is arguably still in its infancy as a field, several recent
breakthroughs have provided the fodder for a story, replete with episodes of apparent mass …

A wide spectrum of alterations in mitochondria and mitochondrial DNA (mtDNA) with aging
has been observed in animals and humans. These include (i) decline in mitochondrial …