The malignant tumor is a multi-etiological, systemic and complex disease characterized by
uncontrolled cell proliferation and distant metastasis. Anticancer treatments including …

Since 1984, when paclitaxel was approved by the FDA for the treatment of advanced
ovarian carcinoma, taxanes have been widely used as microtubule-targeting antitumor …

Interactions between cancer cells and their surroundings can trigger essential signaling
cues that determine cell fate and influence the evolution of the malignant phenotype. As the …

Chemoresistance is a leading cause of morbidity and mortality in cancer and it continues to
be a challenge in cancer treatment. Chemoresistance is influenced by genetic and …

The extracellular matrix (ECM) is a ubiquitous member of the body and is key to the
maintenance of tissue and organ integrity. Initially thought to be a bystander in many cellular …

Rationale: In the glioblastoma (GBM) microenvironment, tumor-associated macrophages
(TAMs) are prominent components and facilitate tumor growth. The exact molecular …

Simple Summary Stroma modifications observed in solid cancer are now recognized as
critical events for cancer progression and as potential therapeutic or diagnostic targets. The …

The tumor microenvironment evolves during malignant progression, with major changes in
nonmalignant cells, cytokine networks, and the extracellular matrix (ECM). In this study, we …

Integrins are the adhesion molecules and receptors of extracellular matrix (ECM). They
mediate the interactions between cells-cells and cells-ECM. The crosstalk between cancer …

The development of most solid cancers, including pancreatic, breast, lung, liver, and ovarian
cancer, involves a desmoplastic reaction: a process of major remodeling of the extracellular …