The 5th edition of the World Health Organization classification of haematolymphoid tumours: lymphoid neoplasms

R Alaggio, C Amador, I Anagnostopoulos, AD Attygalle… - Leukemia, 2022 - nature.com
We herein present an overview of the upcoming 5th edition of the World Health Organization
Classification of Haematolymphoid Tumours focussing on lymphoid neoplasms. Myeloid …

JAK/STAT pathway: Extracellular signals, diseases, immunity, and therapeutic regimens

Q Hu, Q Bian, D Rong, L Wang, J Song… - … in Bioengineering and …, 2023 - frontiersin.org
Janus kinase/signal transduction and transcription activation (JAK/STAT) pathways were
originally thought to be intracellular signaling pathways that mediate cytokine signals in …

DDX3X: structure, physiologic functions and cancer

J Mo, H Liang, C Su, P Li, J Chen, B Zhang - Molecular cancer, 2021 - Springer
The DEAD-box helicase family member DDX3X (DBX, DDX3) functions in nearly all stages
of RNA metabolism and participates in the progression of many diseases, including virus …

[HTML][HTML] Genomic and transcriptomic characterization of natural killer T cell lymphoma

J **ong, BW Cui, N Wang, YT Dai, H Zhang, CF Wang… - Cancer Cell, 2020 - cell.com
Natural killer/T cell lymphoma (NKTCL) is an aggressive and heterogeneous entity of non-
Hodgkin lymphoma, strongly associated with Epstein-Barr virus (EBV) infection. To identify …

The immune checkpoint PD-1 in natural killer cells: expression, function and targeting in tumour immunotherapy

L Quatrini, FR Mariotti, E Munari, N Tumino, P Vacca… - Cancers, 2020 - mdpi.com
Simple Summary Natural killer cells are innate cytotoxic lymphocytes that play a key role in
the anti-tumor immune response. In the tumor microenvironment, however, the effector …

JAK/STAT cytokine signaling at the crossroad of NK cell development and maturation

D Gotthardt, J Trifinopoulos, V Sexl… - Frontiers in …, 2019 - frontiersin.org
Natural Killer (NK) cells are cytotoxic lymphocytes of the innate immune system and play a
critical role in anti-viral and anti-tumor responses. NK cells develop in the bone marrow from …

Peripheral T cell lymphomas: from the bench to the clinic

D Fiore, LV Cappelli, A Broccoli, PL Zinzani… - Nature Reviews …, 2020 - nature.com
Peripheral T cell lymphomas (PTCLs) are a heterogeneous group of orphan neoplasms.
Despite the introduction of anthracycline-based chemotherapy protocols, with or without …

Epstein–Barr virus-associated T-and NK-cell lymphoproliferative diseases: an update and diagnostic approach

SSS Hue, ML Oon, S Wang, SY Tan, SB Ng - Pathology, 2020 - Elsevier
Summary Epstein–Barr virus (EBV)-positive T-cell and natural killer (NK)-cell
lymphoproliferative diseases (EBV-TNKLPD) are a group of uncommon disorders …

Somatic mutations in lymphocytes in patients with immune-mediated aplastic anemia

S Lundgren, MAI Keränen, M Kankainen, J Huuhtanen… - Leukemia, 2021 - nature.com
The prevalence and functional impact of somatic mutations in nonleukemic T cells is not well
characterized, although clonal T-cell expansions are common. In immune-mediated aplastic …

CCL22 mutations drive natural killer cell lymphoproliferative disease by deregulating microenvironmental crosstalk

C Baer, S Kimura, MS Rana, AB Kleist, T Flerlage… - Nature …, 2022 - nature.com
Chronic lymphoproliferative disorder of natural killer cells (CLPD-NK) is characterized by
clonal expansion of natural killer (NK) cells where the underlying genetic mechanisms are …