Polymeric micelles for the delivery of poorly soluble drugs: From nanoformulation to clinical approval

D Hwang, JD Ramsey, AV Kabanov - Advanced drug delivery reviews, 2020 - Elsevier
Over the last three decades, polymeric micelles have emerged as a highly promising drug
delivery platform for therapeutic compounds. Particularly, poorly soluble small molecules …

Micellar nanocarriers: pharmaceutical perspectives

VP Torchilin - Pharmaceutical research, 2007 - Springer
Micelles, self-assembling nanosized colloidal particles with a hydrophobic core and
hydrophilic shell are currently successfully used as pharmaceutical carriers for water …

Polymeric micelles for ocular drug delivery: From structural frameworks to recent preclinical studies

A Mandal, R Bisht, ID Rupenthal, AK Mitra - Journal of Controlled Release, 2017 - Elsevier
Effective intraocular drug delivery poses a major challenge due to the presence of various
elimination mechanisms and physiological barriers that result in low ocular bioavailability …

Advances in characterisation and biological activities of chitosan and chitosan oligosaccharides

P Zou, X Yang, J Wang, Y Li, H Yu, Y Zhang, G Liu - Food chemistry, 2016 - Elsevier
Chitosan and chitosan oligosaccharides (COS) have been reported to possess various
biomedical properties, including antimicrobial activities, immuno-enhancing effects, and anti …

Approved nanomedicine against diseases

Y Jia, Y Jiang, Y He, W Zhang, J Zou, KT Magar… - Pharmaceutics, 2023 - mdpi.com
Nanomedicine is a branch of medicine using nanotechnology to prevent and treat diseases.
Nanotechnology represents one of the most effective approaches in elevating a drug's …

Overcoming the barriers in micellar drug delivery: loading efficiency, in vivo stability, and micelle–cell interaction

S Kim, Y Shi, JY Kim, K Park… - Expert opinion on drug …, 2010 - Taylor & Francis
Importance of the field: Spontaneously constructed from block copolymers in aqueous
media, the polymer micelle has been extensively studied as a potential carrier of poorly …

Polymeric micelles for drug delivery

HM Aliabadi, A Lavasanifar - Expert opinion on drug delivery, 2006 - Taylor & Francis
Polymeric micelles have been the subject of many studies in the field of drug delivery for the
past two decades. The interest has specifically been focused on the potential application of …

Polymeric micelles of biodegradable diblock copolymers: enhanced encapsulation of hydrophobic drugs

YHA Hussein, M Youssry - Materials, 2018 - mdpi.com
Polymeric micelles are potentially efficient in encapsulating and performing the controlled
release of various hydrophobic drug molecules. Understanding the fundamental …

Enhanced solubility and stability of PEGylated liposomal paclitaxel: in vitro and in vivo evaluation

T Yang, FD Cui, MK Choi, JW Cho, SJ Chung… - International journal of …, 2007 - Elsevier
An improved PEGylated liposomal formulation of paclitaxel has been developed with the
purpose of improving the solubility of paclitaxel as well as the physicochemical stability of …

Clinical toxicities of nanocarrier systems

KR Vega-Villa, JK Takemoto, JA Yáñez… - Advanced drug delivery …, 2008 - Elsevier
Toxicity of nanocarrier systems involves physiological, physicochemical, and molecular
considerations. Nanoparticle exposures through the skin, the respiratory tract, the …