Oligodendrocyte precursor cells (OPCs) originate in the ventricular zones (VZs) of the brain
and spinal cord and migrate throughout the develo** central nervous system (CNS) …

Platelet-derived growth factors (PDGF) promotes cell proliferation, survival and migration,
primarily of cells of mesenchymal origin. Dysfunction of PDGF signaling has been observed …

The specific function of microglia, the tissue resident macrophages of the brain and spinal
cord, has been difficult to ascertain because of a lack of tools to distinguish microglia from …

Platelet-derived growth factors (PDGFs) and their receptors (PDGFRs) have served as
prototypes for growth factor and receptor tyrosine kinase function for more than 25 years …

Oligodendrocytes, the myelin-forming cells of the central nervous system (CNS), and
astrocytes constitute macroglia. This review deals with the recent progress related to the …

Glioblastoma (GBM) remains the most lethal and common primary brain tumor, even after
treatment with multiple therapies, such as surgical resection, chemotherapy, and radiation …

Fibrosis is part of a tissue repair response to injury, defined as increased deposition of
extracellular matrix. In some instances, fibrosis is beneficial; however, in the majority of …

NG2 cells (also known as polydendrocytes) are a population of CNS cells that are distinct
from neurons, mature oligodendrocytes, astrocytes and microglia. They can be identified by …

Demyelination in the adult CNS can be followed by extensive repair. However, in multiple
sclerosis, the differentiation of oligodendrocyte lineage cells present in demyelinated lesions …

Multiple sclerosis is a common cause of neurological disability in young adults. The disease
is complex—its aetiology is multifactorial and largely unknown; its pathology is …